DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABL1 and btl

DIOPT Version :10

Sequence 1:NP_009297.2 Gene:ABL1 / 25 HGNCID:76 Length:1149 Species:Homo sapiens
Sequence 2:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:500 Identity:153/500 - (30%)
Similarity:237/500 - (47%) Gaps:105/500 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    90 DFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSN----YITPVNSLEKHSWYHG- 149
            :|..:.|:.: :|    ||.:.::..| |......:|.|...|:    .::|:..||.::..|. 
  Fly   541 NFTVTNDSVV-LT----LRNVTFDQEG-WYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAH 599

Human   150 PVSRNAAE------YLLSSGINGSFLVRESESSPGQRSISLRYE------GRVYHYRI-----NT 197
            |:....|.      :||.|... :|::|....   ::.:.||.|      .:|..||.     :.
  Fly   600 PLGFTLAAITIVALFLLGSAFI-TFMLRRLRR---EKLLKLRIETVHQWTKKVIIYRPGGEEGSG 660

Human   198 ASDGKL---YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP-----NYD-- 252
            .|.|.|   .:..|.:..|:       ||...|                  |..|     .|:  
  Fly   661 CSSGDLQMPVIRIEKQRTTV-------STTGTG------------------GTDPAQGFNEYEFP 700

Human   253 ---KWEMERTDITMKHKLGGGQYGEVY----EGVWKKYSLT---VAVKTLKEDTMEVE--EFLKE 305
               .||:.|..:::...||.|.:|.|.    ||:.:...|.   ||||.:||:..:.:  ..::|
  Fly   701 LDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVRE 765

Human   306 AAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR------------------ 351
            ..|||.| ||.|::.|||.|::..|.::|.|:..:|||.|:|:: ||                  
  Fly   766 MEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQ-NRPGAPQRRSDSDGYLDDKP 829

Human   352 ----QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDT 411
                |.:....|...|.||:..||||..:..|||||||||.||.:.:::|:|||||:| :...:.
  Fly   830 LISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEY 894

Human   412 YTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDY 475
            |..:...:.||||.|||||...|:..:||||::|||||||.|||..|||.| ...::|..|....
  Fly   895 YRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQ 959

Human   476 RMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS 520
            |||:|..|...:|.:||.||.:....||:|||:.::|:.:.|::|
  Fly   960 RMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQAS 1004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABL1NP_009297.2 SH3_Abl 84..137 CDD:212784 10/50 (20%)
SH2_ABL 142..235 CDD:198189 23/113 (20%)
PTKc_Abl 254..516 CDD:270645 113/295 (38%)
FABD 1025..1149 CDD:197885
btlNP_729956.1 Ig 143..215 CDD:472250
Ig strand B 160..164 CDD:409570
Ig strand C 175..179 CDD:409570
Ig strand E 197..201 CDD:409570
Ig strand F 211..215 CDD:409570
Ig_3 247..333 CDD:464046
Ig 398..479 CDD:472250
Ig strand B 412..416 CDD:409393
Ig strand C 423..427 CDD:409393
Ig strand E 445..449 CDD:409393
Ig strand F 459..464 CDD:409393
Ig strand G 472..475 CDD:409393
IG_like 492..583 CDD:214653 10/47 (21%)
Ig strand B 503..507 CDD:409444
Ig strand C 516..520 CDD:409444
Ig strand E 549..553 CDD:409444 1/8 (13%)
Ig strand F 563..568 CDD:409444 1/4 (25%)
Ig strand G 576..579 CDD:409444 1/2 (50%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 113/300 (38%)
Blue background indicates that the domain is not in the aligned region.

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