DRSC/TRiP Functional Genomics Resources

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Protein Alignment ABL1 and sev

DIOPT Version :10

Sequence 1:NP_009297.2 Gene:ABL1 / 25 HGNCID:76 Length:1149 Species:Homo sapiens
Sequence 2:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster


Alignment Length:526 Identity:155/526 - (29%)
Similarity:228/526 - (43%) Gaps:129/526 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   140 SLEKHSWYHGPVSRNA---AEYLLSSGINGSF-------------------LVRESESSPGQRSI 182
            ||| |.|  ||.|..:   ||..:|....||.                   |||:.:.. ..|:.
  Fly  2098 SLE-HGW--GPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKR-RLRAK 2158

Human   183 SLRYEGR--VYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVY 245
            .|..:.|  ::.......:..:|.......|:|         |::|..|..|    |:.|     
  Fly  2159 KLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFST---------TLSDADIALL----PQIN----- 2205

Human   246 GVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLKEDTMEVEEFLKEA 306
                    |    :.:.:...||.|.:||||||..|    :....||:|:|::...|..|.|:||
  Fly  2206 --------W----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEA 2258

Human   307 AVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC---NRQE------VNAVVLLYM 362
            .:|...||.|:|.|:|:|.......:|.|.|..|:||.|||..   :.||      ::...||.|
  Fly  2259 QLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAM 2323

Human   363 ATQISSAMEYLEKKNFIHRDLAARNCLVGEN-------HLVKVADFGLSR-LMTGDTYTAHAGAK 419
            ...:::...|||..:|:|||||.|||||.|:       ..||:.||||:| :...|.|.......
  Fly  2324 CIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGL 2388

Human   420 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 484
            .|::|.:||||....|:.:|||||||||.|||.|.|..||...:..:|...:::..|:::|..|.
  Fly  2389 LPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCT 2453

Human   485 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPT 549
            ||:|.|:..||:.:|.:||||   .:.:.|:.                    |:||.|       
  Fly  2454 EKLYSLLLLCWRTDPWERPSF---RRCYNTLH--------------------AISTDL------- 2488

Human   550 KTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL----L 610
              |.::.|:...||......|..|.:.:..||:..        |:....|     |||.|    :
  Fly  2489 --RRTQMASATADTVVSCSRPEFKVRFDGQPLEEH--------REHNERP-----EDENLTLREV 2538

Human   611 P-KDKK 615
            | |||:
  Fly  2539 PLKDKQ 2544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABL1NP_009297.2 SH3_Abl 84..137 CDD:212784
SH2_ABL 142..235 CDD:198189 24/116 (21%)
PTKc_Abl 254..516 CDD:270645 105/282 (37%)
FABD 1025..1149 CDD:197885
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996
FN3 1993..2111 CDD:238020 8/15 (53%)
PTKc_c-ros 2213..2483 CDD:270640 104/292 (36%)
Blue background indicates that the domain is not in the aligned region.

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