Protein Alignment ABL1 and Abl1

DIOPT Version :9

• Sequence 1: NP_009297.2
• Gene: ABL1 / 25
• HGNCID: 76
• Length: 1149
• Species: Homo sapiens
• Sequence 2: NP_001094320.1
• Gene: Abl1 / 311860
• RGDID: 1584969
• Length: 1143
• Species: Rattus norvegicus
• Alignment Length: 1154
• Identity: 1013/1154 - (87%)
• Similarity: 1056/1154 - (91%)
• Gaps: 16/1154 - (1%)

Human     1 MGQQPGKVLGDQRRPSLPALHFIKGAGKKESSRHGGPHCNVFVEHEALQRPVASDFEPQGLSEAA 65
            ||||||||||||||||||||||||||||::|||||||||||||||||||||||||||||||||||
  Rat     1 MGQQPGKVLGDQRRPSLPALHFIKGAGKRDSSRHGGPHCNVFVEHEALQRPVASDFEPQGLSEAA 65

Human    66 RWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 RWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWV 130

Human   131 PSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 PSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 195

Human   196 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTD 260
            ||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||
  Rat   196 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTD 260

Human   261 ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 325

Human   326 REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 390
            |||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||
  Rat   326 REPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 390

Human   391 GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG 455

Human   456 MSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 MSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS 520

Human   521 ISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEP 585
            |||||||||||:|:|||..:.||||||||||||.|:.||.:|..|..|:.|:||.||||.||.||
  Rat   521 ISDEVEKELGKRGMRGAAGSTLQAPELPTKTRTCRKTAEQKDAPDALELLHTKGLGESDALDSEP 585

Human   586 AVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERR 650
            ||||||||||||||:|.||||||||||||||||||||||||||.|||||||||||||||||.|||
  Rat   586 AVSPLLPRKERGPPDGSLNEDERLLPKDKKTNLFSALIKKKKKMAPTPPKRSSSFREMDGQSERR 650

Human   651 GAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSS 715
            ||.|::||:||||..|.|. |..:|.||||.||||||||||.||.|.|||||||:||||||||||
  Rat   651 GASEDDGREISNGPPALTS-DAVEPTKSPKASNGAGVPNGAFREPGNSGFRSPHVWKKSSTLTSS 714

Human   716 RLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPA 780
            |||..|||.|.||||||||||||||:|||.:|||||||||||||.|.|:||||||||||||||||
  Rat   715 RLAAAEEESGLSSSKRFLRSCSASCMPHGVRDTEWRSVTLPRDLPSAGKQFDSSTFGGHKSEKPA 779

Human   781 LPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAP 845
            |||||..|:||:||.:.|.|||||||||.||||::|||| .|||||||||:||||.|||||..:|
  Rat   780 LPRKRTSESRSEQVAKSTATPPPRLVKKTEEAAEDVFKD-TESSPGSSPPSLTPKLLRRQVPASP 843

Human   846 ASGLPHKEEAGKGSA--LGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDK 908
            :||..||:||.||:|  :||||.|||..|::||      |.||..:||.|.||||||||||||||
  Rat   844 SSGPSHKDEATKGNASGMGTPATAEPAAPSNKA------GLSKASSEEPRARRHKHSSESPGRDK 902

Human   909 GKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSL-VDAVNSDAAKPSQPGE 972
            |:||:||||||||| :|.||| |||:|||||:.||||....|||.||| |||||||..|..||||
  Rat   903 GRLSKLKPAPPPPP-SSTGKA-GKPAQSPSQDVAGEAGGATKTKCTSLSVDAVNSDPTKAGQPGE 965

Human   973 GLKKPVLPATPKPQSA-KPSGTPISPAPVPSTLPSASSALAGD-QPSSTAFIPLISTRVSLRKTR 1035
            ||:|.|.|:.|||||| ||.|||.||...|||.| |.|.|||| ||||.||||||||||||||||
  Rat   966 GLRKSVPPSVPKPQSATKPPGTPTSPVSTPSTAP-APSPLAGDQQPSSAAFIPLISTRVSLRKTR 1029

Human  1036 QPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKF 1100
            |||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1030 QPPERIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKF 1094

Human  1101 AFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR 1149
            ||||||||||:||||||||||||.|||||||||||||||||||||||:|
  Rat  1095 AFREAINKLESNLRELQICPATASSGPAATQDFSKLLSSVKEISDIVRR 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784	52/52 (100%)
		SH2_ABL	142..235	CDD:198189	92/92 (100%)
		PTKc_Abl	254..516	CDD:270645	260/261 (100%)
		Pkinase_Tyr	261..512	CDD:285015	249/250 (100%)
		FABD	1025..1149	CDD:197885	120/123 (98%)
Abl1	NP_001094320.1	SH3_Abl	84..137	CDD:212784	52/52 (100%)
		SH2_ABL	142..235	CDD:198189	92/92 (100%)
		PTKc_Abl	254..516	CDD:270645	260/261 (100%)
		Pkinase_Tyr	261..512	CDD:285015	249/250 (100%)
		FABD	1019..1143	CDD:197885	120/123 (98%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83690599
Domainoid	1	1.000	768	1.000	Domainoid score	I2925
eggNOG	1	0.900	-	-		E2759_KOG4278
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3783
Inparanoid	1	1.050	1916	1.000	Inparanoid score	I1620
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42186
OrthoDB	1	1.010	-	-		D102126at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto139344
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270