DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hoe1 and Oca2

DIOPT Version :9

Sequence 1:	NP_001285607.1	Gene:	hoe1 / 249663	FlyBaseID:	FBgn0041150	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_068679.1	Gene:	Oca2 / 18431	MGIID:	97454	Length:	833	Species:	Mus musculus

Alignment Length:	780	Identity:	314/780 - (40%)
Similarity:	457/780 - (58%)	Gaps:	104/780 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 HHEETALANQPFTQIGINVTNEAGQVRVLDGRDLEN----NNDDQHDEA-EPHAKSLIRKY---L 169
            ||.| .:|.:...:.|:.    |.:.:.:.|:::.:    .:.::.|.| ..|.::.:.|.   :
Mouse   112 HHPE-FIATEGSWENGLT----AWEQKCMLGKEVADLSALASSEKRDLAGSVHLRAQVSKLGCCV 171

  Fly   170 IWFKIA--ILLVVWCVFTAFLMSNNEHVDQLSLISVPRNSSPRVFPIATASLQRIGLGLRGPFRL 232
            .|.||.  .:.||.|.....|..:.....||..:|...|.|..:...|.:.:  :.|.|.|
Mouse   172 RWIKITGLFVFVVLCSILFSLYPDQGKFWQLLAVSPLENYSVNLSGHADSMI--LQLDLAG---- 230

  Fly   233 QENELAINASVPLPLLQVQVMRSYFDGEGMEIYIENASQVWQLDVVYPDLIDATRDTKKQ----- 292
                 |:.|..|             .|.|.|.::          ||.....||..:.:::
Mouse   231 -----ALMAGGP-------------SGSGKEEHV----------VVVVTQTDAAGNRRRRPQQLT 267

  Fly   293 -----------------RTFELSPTDPLWLAQANRTELSFEFTSSIEGE--LPLQL-------NV 331
                             ||||:          .:|..:|....:|::..  :||.|       :|
Mouse   268 YNWTVLLNPRSEHVVVSRTFEI----------VSREAVSISIQASLQQTRLVPLLLAHQFLGASV 322

  Fly   332 DESPIYKRDGVIYAAAVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSRPSMATIMGWIDV 396
            :..       |..|.|:|.|:|.:||:|||:||.||::.:..::..||.:..|||:..::.|||.
Mouse   323 EAQ-------VASAVAILAGVYTLIIFEIVHRTLAAMLGALAALAALAVVGDRPSLTHVVEWIDF 380

  Fly   397 ETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMT 461
            |||.||||||||||:.||||.|||.||.||:::.|.||.:|..|||..|:||:|||||||:||.|
Mouse   381 ETLALLFGMMILVAVFSETGFFDYCAVKAYQLSRGRVWAMIFMLCLMAAILSAFLDNVTTMLLFT 445

  Fly   462 PVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISKNGVNFAVFTLHMLPG 526
            |||||||||:.|:|..:|:..||::|||||.|.:||||||||.||..:.|.|::||.||.||..|
Mouse   446 PVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFLG 510

  Fly   527 VLLVMVQTYIQLRFKFRNISDLQFKDSPEVEELRHEIHVWKRAAASLSAYSKDEELVRQTLMKKV 591
            :.||::.::..||..:.| ..|..|:..|:.||:||||||:..|..:|..|::|..||..|::||
Mouse   511 ICLVLLVSFPLLRLLYWN-KKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRGLLLEKV 574

  Fly   592 NRLKRSLKKRM----TAVIEPAPNYQQTLANLQAKYPIRNKPLLIKCSAALVFVISLFFLHS-VP 651
            ..|:..|.:|:    ..:.:...|::..:..||.|:.|.::.||:||...|.||||:|||:| ||
Mouse   575 LALEHLLAQRLHTFHRQISQEDKNWETNIQELQRKHRISDRSLLVKCLTVLGFVISMFFLNSFVP 639

  Fly   652 ELQRLSLGWTALLGAIFLIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMT 716
            .: .|.|||.|:||||:|:|||||.|.|.||.||||:|||||||||:||||||.|.|:|::|..|
Mouse   640 GI-HLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALTHLHLVEYVGEQT 703

  Fly   717 EGIILGVGEDRRLMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQNSTLNLPLQPLVWALA 781
            ..:|..|.||:|...||::|:||||:||:.:||||.|..|:.:.::|:|:..::||..||::|||
Mouse   704 ALLIKMVPEDQRFAAAIVLIVWVSALASSLIDNIPFTATMIPVLLNLSQDPEISLPALPLMYALA 768

  Fly   782 LGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGSIIVTTGYLLVSHSLFAWH 846
            |||||||||||||||.||||||:||:|||.|:|::||::|||:|:.|..:...|||::|.:..|:
Mouse   769 LGACLGGNGTLIGASTNVVCAGIAEKHGYGFSFMEFFRLGFPVMLMSCTIGMCYLLIAHIVVGWN 833

Fly 847 846
Mouse 834 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hoe1	NP_001285607.1	ArsB	345..839	CDD:223983	263/498 (53%)
hoe1	NP_001285607.1	P_permease	349..837	CDD:238536	259/492 (53%)
Oca2	NP_068679.1	P_permease	333..824	CDD:238536	259/492 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836899
Domainoid	1	1.000	426	1.000	Domainoid score	I610
eggNOG	1	0.900	-	-		E1_COG1055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1248
Isobase	1	0.950	-	0	Normalized mean entropy	S7077
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001813
OrthoInspector	1	1.000	-	-		otm43375
orthoMCL	1	0.900	-	-		OOG6_101594
Panther	1	1.100	-	-	LDO	PTHR43568
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5163
SonicParanoid	1	1.000	-	-		X2794
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.730