DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hoe1 and oca2

DIOPT Version :9

Sequence 1:	NP_001285607.1	Gene:	hoe1 / 249663	FlyBaseID:	FBgn0041150	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_012813149.2	Gene:	oca2 / 100487559	XenbaseID:	XB-GENE-989255	Length:	858	Species:	Xenopus tropicalis

Alignment Length:	786	Identity:	321/786 - (40%)
Similarity:	470/786 - (59%)	Gaps:	92/786 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 GHHEETAL--------------ANQPFTQIGIN--------------VTNEAGQVRVLDGRDLEN 148
            |:.|:|.|              .|:|....|::              :.:|.|.:    .|.:..
Frog   113 GYTEKTPLLNFSSENKQSQCKAVNRPEFLFGVDSLENSSSEFEQRCRLGSEVGSL----SRSVST 173

  Fly   149 NNDDQHDEAEPHAK-SLIRKYLIWFKIAIL--LVVWCVFTAFLMSNNEHVDQLSLISVPRNSSPR 210
            ..::..|..:.... |..|.:|...|||:|  :||.|.......|:.....|:..:|...:.|..
Frog   174 EKNELLDNLQEKLNFSKFRCFLKNLKIAVLFIIVVTCSVLFSTSSDKSSPWQMLALSSMESFSGN 238

  Fly   211 VFPIATASLQRIGLGLRGPF-------RLQENELAINASVPLPLLQVQVMRSYFDGEGMEIYIEN 268
            :.....|:|  :.|.:.|||       |..|            .:.||:.::    |........
Frog   239 LTDFRNAAL--LKLQIDGPFAGDLLDPRNDE------------YILVQITQT----EDPVSRRRR 285

  Fly   269 ASQV---WQLDVVYPDLIDATRDTK---KQRTFELSPTDPLWLAQANRTELSFEFTSSIEGE--L 325
            :|||   |.|.:       ::|..:   :::|||:..:|          .:|....:.::|.  :
Frog   286 SSQVTYNWTLPL-------SSRRKEHIIREKTFEILDSD----------TISINIQAFLQGTQLV 333

  Fly   326 PLQLNVDESPIYKRDGVIYAAAVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSRPSMATI 390
            ||.|:...........|..||.||.|:||:||:|||:||.||::.|..::..||.:..|||:..:
Frog   334 PLSLSHQYLSASIETQVTIAAVVLAGVYVLIIFEIVHRTLAAMLGSLAALAALALVGDRPSLVKV 398

  Fly   391 MGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVT 455
            :.|||.|||.||||||||||:.|:||.|||.||.||:::.|.:||:|..|||..|:||:||||||
Frog   399 VEWIDYETLALLFGMMILVAVFSDTGFFDYCAVKAYQLSRGRIWPMIIILCLIAAILSAFLDNVT 463

  Fly   456 TVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISKNGVNFAVFT 520
            |:||.||||||||||:.|:|..:|:..||::|||||.|.|||||||||.||..:.|..::||.||
Frog   464 TMLLFTPVTIRLCEVLNLDPRHVLIAEVIFTNIGGAATAVGDPPNVIIVSNQELRKVELDFAGFT 528

  Fly   521 LHMLPGVLLVMVQTYIQLRFKFRNISDLQFKDSPEVEELRHEIHVWKRAAASLSAYSKDEELVRQ 585
            .||..|:.||::.::..||..:.| ..|..|:..|:.||:||||||:..|..::..|::|..|:.
Frog   529 GHMFLGICLVLLVSFPFLRILYWN-KKLYNKEPSEIVELKHEIHVWRLTAQRINPASREETAVKC 592

  Fly   586 TLMKKVNRLKRSLKKRMTA----VIEPAPNYQQTLANLQAKYPIRNKPLLIKCSAALVFVISLFF 646
            .||:||.:|:..|:|::..    :.:...|::..:..||.::.|.:|.|||||.:.|.|||.:||
Frog   593 LLMQKVLKLESLLRKKLQTFQRQISQEDKNWETNIQELQKRHGISDKILLIKCLSVLGFVIFMFF 657

  Fly   647 LHS-VPELQRLSLGWTALLGAIFLIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIE 710
            |:| |||: .|.|||.|:||:::|::|||:.|.|.||.||||:|||||||||:|||||..|.|||
Frog   658 LNSFVPEI-HLDLGWIAILGSLWLLVLADVHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIE 721

  Fly   711 WIGNMTEGIILGVGEDRRLMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQNSTLNLPLQP 775
            :||..|..:|..|.||.||.:||::::||||:||:.:||||.|..|:.:.|:|:|::.:|||::|
Frog   722 YIGEQTALLIKAVPEDERLAIAIILVVWVSALASSLIDNIPFTATMIPVLINLSQDADVNLPIKP 786

  Fly   776 LVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGSIIVTTGYLLVSH 840
            |::|||:|||||||||||||||||||||:||||||.|:|::||::|||:||.|..:...||||:|
Frog   787 LIFALAIGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMIVSTAIGMCYLLVAH 851

  Fly   841 SLFAWH 846
            .:..|:
Frog   852 VVLGWN 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hoe1	NP_001285607.1	ArsB	345..839	CDD:223983	266/498 (53%)
hoe1	NP_001285607.1	P_permease	349..837	CDD:238536	261/492 (53%)
oca2	XP_012813149.2	P_permease	357..848	CDD:238536	261/492 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	430	1.000	Domainoid score	I590
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1181
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D150165at33208
OrthoFinder	1	1.000	-	-		FOG0001813
OrthoInspector	1	1.000	-	-		otm48523
Panther	1	1.100	-	-	LDO	PTHR43568
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2794
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070