| Sequence 1: | NP_058767.2 | Gene: | Insr / 24954 | RGDID: | 2917 | Length: | 1384 | Species: | Rattus norvegicus |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_524625.3 | Gene: | Eph / 43803 | FlyBaseID: | FBgn0025936 | Length: | 1096 | Species: | Drosophila melanogaster |
| Alignment Length: | 1101 | Identity: | 266/1101 - (24%) |
|---|---|---|---|
| Similarity: | 426/1101 - (38%) | Gaps: | 303/1101 - (27%) |
- Green bases have known domain annotations that are detailed below.
|
Rat 386 GLIEE-ISGFLK-IR-RSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQ-NLR--QLWDWNKH 444
Rat 445 NLTITQGKLFFHYN------PKLCLSEIHKMEEVSGTKGRQERN-DIALKTNGDQASCENELLKF 502
Rat 503 SFIRTSFDKILLRWEPYWPPDFRD------LLGFMLFYKEAP--YQNVTEFD----GQD--ACGS 553
Rat 554 NSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQ 618
Rat 619 TDATN-------------PSV----PLDPISVSNSSSQIILK-----------------WKPPSD 649
Rat 650 PNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPP-----FESDDSQK--HNQSEYDDS 707
Rat 708 ASECCSC-------PKTDS-----QILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDTRPS 760
Rat 761 RKRRSLEEVGNVTATTPTLPDFPNISSTIAPTSHEEHR--PFEKVVNKESLVISGLRHFTGYRIE 823
Rat 824 LQA-CNQDSPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYE 887
Rat 888 VSYRRYGDEELHLCVSRKHFALERGCRLRGLSPG-NYSVRVRATSLAGNGSWTEPTYFYV----- 946
Rat 947 ---TDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDG---------PMGPLYASSNP 999
Rat 1000 EYLSASDVFP----------------SSVYV-PDEWEVPREK------------ITLLRELGQGS 1035
Rat 1036 FGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQP 1100
Rat 1101 TLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAAR 1165
Rat 1166 NCMVAHDFTVKIGDFGMTRDIYETD--YYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVL 1228
Rat 1229 WEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLK 1293
Rat 1294 DDL----------HPSFPEVSFFYSEENKAPESEELEMEFED----MENVPLDRSSHCQRE 1340 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Insr | NP_058767.2 | Recep_L_domain | 52..164 | CDD:279382 | |
| Furin-like | 179..337 | CDD:279142 | |||
| FU | 234..281 | CDD:238021 | |||
| Recep_L_domain | 359..472 | CDD:279382 | 18/97 (19%) | ||
| FN3 | 624..>667 | CDD:238020 | 12/63 (19%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 688..710 | 7/28 (25%) | |||
| Insulin-binding. /evidence=ECO:0000250 | 735..743 | 1/7 (14%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 748..784 | 5/35 (14%) | |||
| FN3 | 869..946 | CDD:238020 | 19/77 (25%) | ||
| Important for interaction with IRS1, SHC1 and STAT5B | 998..1001 | 0/2 (0%) | |||
| PTKc_InsR | 1018..1305 | CDD:133192 | 121/310 (39%) | ||
| Pkinase_Tyr | 1025..1292 | CDD:285015 | 112/268 (42%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1362..1384 | ||||
| PIK3R1 binding. /evidence=ECO:0000250 | 1363..1366 | ||||
| Eph | NP_524625.3 | EphR_LBD | 85..260 | CDD:198439 | 29/168 (17%) |
| FN3 | 387..476 | CDD:238020 | 24/121 (20%) | ||
| FN3 | 536..623 | CDD:238020 | 24/126 (19%) | ||
| EphA2_TM | 644..736 | CDD:291255 | 20/97 (21%) | ||
| PTKc_EphR | 736..1002 | CDD:270629 | 114/277 (41%) | ||
| Pkinase_Tyr | 741..999 | CDD:285015 | 112/268 (42%) | ||
| SAM_1 | 1033..1092 | CDD:278937 | 5/22 (23%) | ||
| SAM | 1039..1092 | CDD:197735 | 4/16 (25%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||