DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gabra3 and GluClalpha

DIOPT Version :9

Sequence 1:	NP_058765.3	Gene:	Gabra3 / 24947	RGDID:	2648	Length:	493	Species:	Rattus norvegicus
Sequence 2:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster

Alignment Length:	446	Identity:	157/446 - (35%)
Similarity:	239/446 - (53%)	Gaps:	52/446 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    69 RILDRLLDG--YDNRLRP-GLG--DAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLK 128
            ::||::|..  ||.|:|| |:.  |....|:.:|:|.|...:.|..|||::.:.||:.|.|||||
  Fly    35 KVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99

  Rat   129 FD---GPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAE 190
            ||   |.:|.|.|..  |:::|.||.||.|.|:...||:..||..:|:..||::||::|:::...
  Fly   100 FDDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLA 162

  Rat   191 CPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEII 255
            |||:|:.:|:|...|.|:..||.:|..::::.|..|  ..|:|.:: ..|.::.|...:......
  Fly   163 CPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEG--DPVQVVKN-LHLPRFTLEKFLTDYCNS 224

  Rat   256 RSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTT 320
            :::||||..:......||:..|::||.|:||.|.||:|.|||||::.:||||...||||:|||.|
  Fly   225 KTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMAT 289

  Rat   321 LSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTP 385
            .:.....|||.|:|..|:|.:..||..|||.||:|||.||| ..||.:.:.....|  .||||..
  Fly   290 QTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNY-ASRSGSNKANMHKE--NMKKKRR 351

  Rat   386 AAPTKKTSTTFNIVGTTYPINLAKDTEFSTISKAAAAPSASSTPTV------------------I 432
            ...........:::.|......|..::|       |.......|.|                  :
  Fly   352 DLEQASLDAASDLLDTDSNATFAMASQF-------ARGGGQQKPLVRHPGDPLALEKRLQCEVHM 409

  Rat   433 ASPK-----TTYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRE 483
            .:||     .|::...|..:|      ::|.||||.||::||:||||||:||:.||
  Fly   410 QAPKRPNCCKTWLSKFPTRSK------RIDVISRITFPLVFALFNLVYWSTYLFRE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gabra3	NP_058765.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..54
		LIC	69..479	CDD:273305	153/440 (35%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	70/206 (34%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	153/440 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910