Protein Alignment NR5A2 and Hr39

DIOPT Version :9

• Sequence 1: NP_995582.1
• Gene: NR5A2 / 2494
• HGNCID: 7984
• Length: 541
• Species: Homo sapiens
• Sequence 2: NP_476932.1
• Gene: Hr39 / 35398
• FlyBaseID: FBgn0261239
• Length: 808
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 166/587 - (28%)
• Similarity: 259/587 - (44%)
• Gaps: 154/587 - (26%)

Human    20 PIGAGLPDRHG----------SPIPARGRLVMLPKVET-----EALGLARSHGEQGQMPEN-MQV 68
            |.|....:.||          |.:|:.|:......:::     :.:||..||      |.: ..:
  Fly   308 PAGTLYGNHHGIYRQMKVEASSTVPSSGQEAQNLSMDSASSNLDTVGLGSSH------PASPAGI 366

Human    69 SQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKT 133
            |:.:::|        ..||:||||:||:|||:.:||||||||||||||.|.|.|:....||:..:
  Fly   367 SRQQLIN--------SPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSIS 423

Human   134 QRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKF-----------GPMYKRDRALKQQKKALIR 187
            .||:||.|||:|||..||||||:|.||.||||:.:           .|:...|:|......|.:.
  Fly   424 TRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAAAAAAAAVA 488

Human   188 ANGLKLEAMSQVIQAMPSDLTISSAIQNIHSAS--KGLPLNHAALPPTDYDRSPFVTSPISMTMP 250
            :            |..|.        |.:|..:  .|:|:                  |.|.::|
  Fly   489 S------------QQQPH--------QRLHQLNGFGGVPI------------------PCSTSLP 515

Human   251 PHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCE--- 312
            ...||.|         .::|||.           |..:...|.:|   .|:|.|:.|::..|
  Fly   516 ASPSLAG---------TSVKSEE-----------MAETGKQSLRT---GSVPPLLQEIMDVEHLW 557

Human   313 ----PDEPQVQAKIMAYLQQEQANRSK-------HEK-----LSTFGL--------------MCK 347
                .:..::...:.|:.....::.|.       |.:     |::.||              :|.
  Fly   558 QYTDAELARINQPLSAFASGSSSSSSSSGTSSGAHAQLTNPLLASAGLSSNGENANPDLIAHLCN 622

Human   348 MADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVD 412
            :||..|:.||:|.:|...|:.:.:|||:.||.|.|.|||:....:|.:  ...|.|.:..|:::.
  Fly   623 VADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSI--DTPGEIKMSQGRKIT 685

Human   413 YSIIASQAGAT----LNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGV 473
            .|...|....|    :.||..|       ||.|:.|:.|:|.:|.:||...|...|:....|...
  Fly   686 LSQAKSNGLQTCIERMLNLTDH-------LRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVREC 743

Human   474 QEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNG-DVPYNNLLIEMLH 537
            ||:...:|..||:.:||....|||:||||:|:::......:|.|..|..:| |.   |||:|:|.
  Fly   744 QEKALQSLQAYTLAHYPDTPSKFGELLLRIPDLQRTCQLGKEMLTIKTRDGADF---NLLMELLR 805

Human   538 AK 539
            .:
  Fly   806 GE 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NR5A2	NP_995582.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		5/24 (21%)
		NR_DBD_Lrh-1_like	86..178	CDD:143541	55/102 (54%)
		FTZ-F1 box	155..184		11/39 (28%)
		NR_LBD_Lrh-1	301..541	CDD:132754	76/277 (27%)
		Phosphatidylglycerol phosphate binding. /evidence=ECO:0000269|PubMed:15897460	421..424		1/6 (17%)
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	53/91 (58%)
		NR_LBD_F2	617..779	CDD:132728	56/170 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950