DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adrb1 and Octbeta1R

DIOPT Version :9

Sequence 1:	NP_036833.1	Gene:	Adrb1 / 24925	RGDID:	2059	Length:	466	Species:	Rattus norvegicus
Sequence 2:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	158/495 - (31%)
Similarity:	236/495 - (47%)	Gaps:	87/495 - (17%)

- Green bases have known domain annotations that are detailed below.

  Rat     9 GASEPCNLSSAAPLPDGAATAARLL----------------------------VLASPPASLLPP 45
            |.:||  |:|..|:.:.:|:.||.|                            |:|.....:  .
  Fly    29 GTNEP--LASKIPVLEESASHARYLKFIADGLIDEGLGSAVGSGSSIAVSVEDVVAGQAQDI--Q 89

  Rat    46 ASEGSAPLSQQWTAGMGL------LLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASAD 104
            |||||.. ....::.:.|      ::..|:|..::||:||||::.:..:|:.:||.|::|||.||
  Fly    90 ASEGSTD-DADGSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVAD 153

  Rat   105 LVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSL 169
            :::.|..:.|.|::::.|:|.:||..|::|.|.||...||||..||.|::|||.||..|..|..:
  Fly   154 MLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLI 218

  Rat   170 LTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFY 234
            :|:.|...::..||...||:|||||...|: ..::..:...::|..|:|..|:||||.||.:||:
  Fly   219 MTQRRVFIMLLMVWLSPALLSFLPICSGWY-TTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFW 282

  Rat   235 VPLCIMAFVYLRVFREAQKQVKKI-DSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKR 298
            :|..:|..:|.|:::||.:|.:.: .|.....|.......|..|.     |||:..:.....|..
  Fly   283 IPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPK-----PRPSIQVEQSTISTM 342

  Rat   299 RPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFV-FFNWLGYANSAFN 362
            |       ||:||.:||||||..|.:|||||||..:|.:.....:..||.| ...|:||.|||.|
  Fly   343 R-------RERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALN 400

  Rat   363 PIIYCR-SPDFRKAFQRLLCCARRAA---CRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDD 423
            ||||.. :.|||.||::.|......|   |||                       |...|||.|.
  Fly   401 PIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRR-----------------------GRGRDDDRDL 442

  Rat   424 AGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSE 463
            ....|..|      |.||...|....:.:........|||
  Fly   443 EFGGPSRR------GTNGAQRTGSGSAEMANCVNSTASSE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adrb1	NP_036833.1	7tm_1	75..366	CDD:278431	112/292 (38%)
		7tm_4	76..>267	CDD:304433	72/191 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..302		8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..466		14/66 (21%)
		PDZ-Binding. /evidence=ECO:0000250	463..466		1/1 (100%)
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	45/118 (38%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	112/292 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2359
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44908
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020