DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32236 and Ppid

DIOPT Version :9

Sequence 1:	NP_729026.1	Gene:	CG32236 / 249170	FlyBaseID:	FBgn0046793	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_080628.1	Gene:	Ppid / 67738	MGIID:	1914988	Length:	370	Species:	Mus musculus

Alignment Length:	192	Identity:	37/192 - (19%)
Similarity:	67/192 - (34%)	Gaps:	57/192 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 PIIYFDMAVRENNQFMGRLLLQLYTELSPEVVLEFVRMATHND------------VGC--HRFVR 278
            |.::||:.:  ..:.:||::|:|:.::.|:....|..:.|...            .||  ||.::
Mouse    16 PRVFFDVDI--GGERVGRIVLELFADIVPKTAENFRALCTGEKGTGSTTGKPLHFKGCPFHRIIK 78

  Fly   279 -------IFSNLWMEAELVPAVHDSLHNHHSVKYSFLDPSKITGVLSYPWDYRRHFPQGLLSYT- 335
                   .|||  .......:::.......:..|                   :|..:||||..
Mouse    79 KFMIQGGDFSN--QNGTGGESIYGEKFEDENFHY-------------------KHDREGLLSMAN 122

  Fly   336 -------ISFKQSVIP-----WQRVIFGRVCGGLRVLQNCHEFGTKNGKTKKTVIVTRCGLL 385
                   ..|..:.:|     .:.|:||:|..||.|.:..........|..|..::..||.|
Mouse   123 AGPNTNGSQFFITTVPTPHLDGKHVVFGQVIKGLGVARTLENVEVNGEKPAKLCVIAECGEL 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32236	NP_729026.1	KIAA1430	85..177	CDD:290590
CG32236	NP_729026.1	cyclophilin	227..385	CDD:294131	36/190 (19%)
Ppid	NP_080628.1	cyclophilin_ABH_like	16..182	CDD:238907	34/188 (18%)
		Chaperone activity. /evidence=ECO:0000250	185..215		37/192 (19%)
		Interaction with HSP90AB1. /evidence=ECO:0000250	214..370
		TPR_11	223..304	CDD:290150
		TPR repeat	223..251	CDD:276809
		TPR repeat	272..302	CDD:276809
		TPR_11	277..338	CDD:290150
		TPR	277..306	CDD:197478
		TPR repeat	307..335	CDD:276809
		TPR_1	308..340	CDD:278916
		TPR repeat	341..364	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810