DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32236 and NKTR

DIOPT Version :9

Sequence 1:	NP_729026.1	Gene:	CG32236 / 249170	FlyBaseID:	FBgn0046793	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001336053.1	Gene:	NKTR / 4820	HGNCID:	7833	Length:	1463	Species:	Homo sapiens

Alignment Length:	188	Identity:	39/188 - (20%)
Similarity:	76/188 - (40%)	Gaps:	46/188 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 RPIIYFDMAVRENNQFMGRLLLQLYTELSPEVVLEFVRMAT-HNDVG-------CHR---FVRIF 280
            ||..:||:.:  |.:.:||::.||::::.|:....|:.:.: ...:|       |::   |.|:.
Human     6 RPQCHFDIEI--NREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVV 68

  Fly   281 SNLWME----AELVPAVHDSLHNHHSVKYSFLDPSKITGVLSYPWDYRRHFPQGLLS-------- 333
            .|..::    :|......:|::..:     |.|.:.|.          :|....|||
Human    69 KNFMIQGGDFSEGNGKGGESIYGGY-----FKDENFIL----------KHDRAFLLSMANRGKHT 118

  Fly   334 ----YTISFKQSV-IPWQRVIFGRVCGGLRVLQNCHEFGT-KNGKTKKTVIVTRCGLL 385
                :.|:.|.:. :....|:||.|..|..|::......| ...:....|.|..||:|
Human   119 NGSQFFITTKPAPHLDGVHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVL 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32236	NP_729026.1	KIAA1430	85..177	CDD:290590
CG32236	NP_729026.1	cyclophilin	227..385	CDD:294131	38/186 (20%)
NKTR	NP_001336053.1	cyclophilin	7..174	CDD:320812	35/183 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..591
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..627
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..1072
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1169..1215
		Arg/Ser tandem repeat-rich	1311..1348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810