DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32236 and CWC27

DIOPT Version :9

Sequence 1:	NP_729026.1	Gene:	CG32236 / 249170	FlyBaseID:	FBgn0046793	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_005860.2	Gene:	CWC27 / 10283	HGNCID:	10664	Length:	472	Species:	Homo sapiens

Alignment Length:	178	Identity:	44/178 - (24%)
Similarity:	65/178 - (36%)	Gaps:	51/178 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 RRLK-----SIKSAG------------DSLGFHARLLNRSQLAGEFNQKQEIFRKNMELLGRINK 133
            ::||     ::||||            :.|...||.|.|..||.: .:|.|...|..|......:
Human   287 KKLKKDTSANVKSAGEGEVEKKSVSRSEELRKEARQLKRELLAAK-QKKVENAAKQAEKRSEEEE 350

  Fly   134 TNRLKGGVDSFNRH---FPALQSNRNKIRELADRLSQENRQLGCRLSQVKSK------------- 182
            ... .|.|..:.|.   :.||:..::|     ...|:|::.|.. |:|.|||
Human   351 APP-DGAVAEYRREKQKYEALRKQQSK-----KGTSREDQTLAL-LNQFKSKLTQAIAETPENDI 408

  Fly   183 ----VDSHNPWVPPVKPLEQK------ASDETVSTFLPYMPSPRLGKR 220
                |:....|:..|...|.|      ||.:...||..|.|...:.||
Human   409 PETEVEDDEGWMSHVLQFEDKSRKVKDASMQDSDTFEIYDPRNPVNKR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32236	NP_729026.1	KIAA1430	85..177	CDD:290590	26/110 (24%)
CG32236	NP_729026.1	cyclophilin	227..385	CDD:294131
CWC27	NP_005860.2	cyclophilin_CeCYP16-like	8..178	CDD:238906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..386		25/105 (24%)
		DUF5401	<302..>472	CDD:375164	38/163 (23%)
		CWC27_CTD	376..428	CDD:412084	12/57 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..472		13/59 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900