DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kpnb1 and Fs(2)Ket

DIOPT Version :9

Sequence 1:	NP_058759.2	Gene:	Kpnb1 / 24917	RGDID:	2909	Length:	876	Species:	Rattus norvegicus
Sequence 2:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster

Alignment Length:	876	Identity:	541/876 - (61%)
Similarity:	677/876 - (77%)	Gaps:	3/876 - (0%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSL 65
            |:||.|||||||||:.||.:|:.|||:||..|||.||..||.:|.|..||.|||:|||||:||.|
  Fly     7 MQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHL 71

  Rat    66 TSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVSQWPELI 130
            ||||..:..|||.||....:..|..:||.:|..||||..|||.|:||||.:|..|:|:::||.||
  Fly    72 TSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLI 136

  Rat   131 PQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAAT 195
            ..||..|.:..|:|..:||.|||||||||||....::::||::|||||.||||.||||:|:||||
  Fly   137 QTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAAT 201

  Rat   196 NALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPAL 260
            .||.|||||||:||:|:.||:|||:||||||||.|:::.|||||.|||||:|||||||.||..||
  Fly   202 TALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQAL 266

  Rat   261 FAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPI 325
            |.||:.|||||.|.||||||||||||||||:|||||:.||.:|||.|:..||.||:||||:|.|:
  Fly   267 FPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPV 331

  Rat   326 LTQTLTKQDENDDDDDWNPCKAAGVCLMLLSTCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAF 390
            |.:.||||||.||:|.|:|.|||.||||:|:|||||:|||||||||||:|::|:||:||||||.|
  Fly   332 LVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTF 396

  Rat   391 GSILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAINDVYLAPLLQC 455
            ||:|.|.|.|.|||||.|||||||.||.|.||:||||.|||.||||:::||||||:.||..||:|
  Fly   397 GSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLEC 461

  Rat   456 LIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGH 520
            .::.|.:|||||:||||||..|::||:||| |.:|.|.|.||.||..||.|:.:|||||||.||.
  Fly   462 FVKSLKSEPRVAANVCWAFIGLSDAAWEAA-VTNDGETPETYALSPYFEYIITQLLETTDRSDGA 525

  Rat   521 QNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLC 585
            |.|||.:||::||:::|||..|||..||:|||||:|||.||:|||:.|.:.|||.||||||||||
  Fly   526 QANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLC 590

  Rat   586 ATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAG-SGGVQEDALMAVSTLVEVLGGEFLKYMEA 649
            ||||:|||||..|||.||||.:|.:||.||.|:|| ||.|||:|.:|||||||:||.:|.|||.|
  Fly   591 ATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPA 655

  Rat   650 FKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNILPFCDEVMQLLLENLGNENVHRSVKPQIL 714
            ||.||.:||||:.|||||.|||||.||:.|||:..::|:.:|:|.:|:.||....:||:||||:|
  Fly   656 FKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVL 720

  Rat   715 SVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDFDMVDYLNELRESCLEAYTGIVQGLKGD 779
            |.||||||:||..|..||.:||:.|:.||..|.|.::|||.:|:||||||.|||||||:|||||.
  Fly   721 SAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGV 785

  Rat   780 QENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIH 844
            .:..|.|||.::|.:..|:|||..||.:.|.:|.::|.|||.||||||:||..:..|:: ..:|.
  Fly   786 DQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLD-DAIIT 849

  Rat   845 ELLTEGRRSKTNKAKTLATWATKELRKLKNQ 875
            :.|.||:|||..:.|.|.|||.||::|:..|
  Fly   850 QFLAEGKRSKAQRTKMLCTWAVKEIKKINTQ 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kpnb1	NP_058759.2	KAP95	2..871	CDD:227540	538/869 (62%)
		HEAT 1. /evidence=ECO:0000250\|UniProtKB:Q14974	2..31		19/28 (68%)
		HEAT 3. /evidence=ECO:0000250\|UniProtKB:Q14974	85..123		18/37 (49%)
		HEAT repeat	128..160	CDD:293787	17/31 (55%)
		HEAT 4. /evidence=ECO:0000250\|UniProtKB:Q14974	129..160		17/30 (57%)
		HEAT repeat	169..200	CDD:293787	22/30 (73%)
		HEAT 5. /evidence=ECO:0000250\|UniProtKB:Q14974	170..202		23/31 (74%)
		HEAT repeat	211..244	CDD:293787	22/32 (69%)
		HEAT 6. /evidence=ECO:0000250\|UniProtKB:Q14974	212..247		24/34 (71%)
		HEAT 7. /evidence=ECO:0000250\|UniProtKB:Q14974	253..302		37/48 (77%)
		HEAT 8. /evidence=ECO:0000250\|UniProtKB:Q14974	314..360		30/45 (67%)
		HEAT repeat	323..354	CDD:293787	19/30 (63%)
		IAB-binding	329..342		9/12 (75%)
		Ran-GTP binding. /evidence=ECO:0000250	334..419		62/84 (74%)
		HEAT repeat	367..395	CDD:293787	20/27 (74%)
		HEAT 10. /evidence=ECO:0000250\|UniProtKB:Q14974	402..438		28/35 (80%)
		HEAT repeat	408..438	CDD:293787	23/29 (79%)
		HEAT 11. /evidence=ECO:0000250\|UniProtKB:Q14974	449..485		20/35 (57%)
		HEAT repeat	451..476	CDD:293787	15/24 (63%)
		HEAT 12. /evidence=ECO:0000250\|UniProtKB:Q14974	500..537		21/36 (58%)
		HEAT repeat	503..535	CDD:293787	20/31 (65%)
		HEAT 13. /evidence=ECO:0000250\|UniProtKB:Q14974	544..592		34/47 (72%)
		HEAT 14. /evidence=ECO:0000250\|UniProtKB:Q14974	600..639		26/39 (67%)
		HEAT 15. /evidence=ECO:0000250\|UniProtKB:Q14974	644..681		25/36 (69%)
		HEAT 16. /evidence=ECO:0000250\|UniProtKB:Q14974	686..724		20/37 (54%)
		HEAT 17. /evidence=ECO:0000250\|UniProtKB:Q14974	732..776		26/43 (60%)
		HEAT 18. /evidence=ECO:0000250\|UniProtKB:Q14974	786..829		22/42 (52%)
		HEAT 19. /evidence=ECO:0000250\|UniProtKB:Q14974	831..873		16/41 (39%)
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	531/860 (62%)
		IBN_N	27..107	CDD:281761	42/79 (53%)
		HEAT repeat	136..162	CDD:293787	12/25 (48%)
		HEAT repeat	179..209	CDD:293787	22/29 (76%)
		HEAT repeat	223..255	CDD:293787	23/31 (74%)
		HEAT repeat	264..291	CDD:293787	20/26 (77%)
		HEAT repeat	330..360	CDD:293787	19/29 (66%)
		HEAT repeat	373..401	CDD:293787	20/27 (74%)
		HEAT_EZ	386..441	CDD:290247	40/54 (74%)
		HEAT repeat	414..444	CDD:293787	23/29 (79%)
		HEAT repeat	457..482	CDD:293787	15/24 (63%)
		HEAT repeat	508..540	CDD:293787	20/31 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353544
Domainoid	1	1.000	495	1.000	Domainoid score	I348
eggNOG	1	0.900	-	-		E1_COG5215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1707
Inparanoid	1	1.050	1052	1.000	Inparanoid score	I243
OMA	1	1.010	-	-		QHG56400
OrthoDB	1	1.010	-	-		D222415at33208
OrthoFinder	1	1.000	-	-		FOG0003173
OrthoInspector	1	1.000	-	-		oto96776
orthoMCL	1	0.900	-	-		OOG6_101642
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2136
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770