DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a1 and CG7458

DIOPT Version :9

Sequence 1:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus
Sequence 2:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	153/556 - (27%)
Similarity:	263/556 - (47%)	Gaps:	37/556 - (6%)

- Green bases have known domain annotations that are detailed below.

  Rat     3 TVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQA 67
            ::|.:|.::|:||.:|...::|||:.....|...:..||...|..|.|..|.....|     |..
  Fly    37 SLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPS-----SVY 96

  Rat    68 EE--LNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDP-----LSSLVANRSQLPLGPCEHG 125
            ||  |.:|:|     .:.|....|.||..:.:.:.....||     |.......|:    .|...
  Fly    97 EEDWLGFTIP-----KKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSE----TCGRD 152

  Rat   126 WVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVS 190
            :.:.....:|.|||.:.|.|.||:.:..:..|:|.|:|..:.||.|||:||:..|.|...|:::.
  Fly   153 FKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALM 217

  Rat   191 GVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGV 255
            ||:.:::.:|:..|:|..|...|....:.:.:.|..|.||...|...|.:..:.:.:|...|..:
  Fly   218 GVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFL 282

  Rat   256 AYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGK-VPPADLK 319
            |..:..||||...:..|..|.:|:.|.:|||.||||||....:|..::.:.|:.|.: :|...|.
  Fly   283 ASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLN 347

  Rat   320 MLCLEEDASEKRSPSFADLFRTPNLRKHTVILMYL--------WFSCAVLYQGLIMHVGATGANL 376
            .|.    .|.::..|.|:..:.|.:|  .|:...|        ||:..::..||.::....|.|.
  Fly   348 DLL----TSNRQKLSQANESQYPIMR--AVVFFSLRIANCCLCWFTHTLIALGLSLNSVNLGGNK 406

  Rat   377 YLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRM 441
            |.:|..:..::.|...:.||.:||:||.:.:.||.|:..........:|.:.:..::.|..:|::
  Fly   407 YTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKL 471

  Rat   442 GATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLT 506
            ..|...|::....:|::||.:||..:.:||.:..:|.:..| ....|.:.:...|.|||....|.
  Fly   472 AITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAP-QTPLLAKYYIYAPQILFATFALI 535

  Rat   507 AGAMTLLLPETKGVALPETIEEAENLGRRKSKAKEN 542
            :|.:||..|||....||.|||||.:|.:.|.:::.:
  Fly   536 SGFLTLAFPETADKVLPTTIEEARDLNQAKRRSERS 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	144/528 (27%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	109/398 (27%)
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	144/528 (27%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	109/389 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960