DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a1 and SLC22A

DIOPT Version :9

Sequence 1:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus
Sequence 2:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	169/558 - (30%)
Similarity:	262/558 - (46%)	Gaps:	45/558 - (8%)

- Green bases have known domain annotations that are detailed below.

  Rat     3 TVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGH-----YCQNPGVAELSQRC 62
            |:|.:|:.:|:||.||...|||:||.....|...|..||...|..|     .|..||........
  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT 90

  Rat    63 GWSQAEELNYTVPGLGPSDEASFLSQCMRYE----VDWNQSTLDCVDPLSS--LVANRSQLPLGP 121
            .||        :|..|..     |..|.||.    ..||.|    ||..|:  ...|:.     .
  Fly    91 NWS--------IPKNGKD-----LDSCNRYTNSELPQWNHS----VDICSADHFTKNKE-----A 133

  Rat   122 CEHG-WVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTL 185
            |.|. :|:.....:|..:|.:.|.|.||:.:..:..|||.|.|..:.|::|||:||...:.:..:
  Fly   134 CAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGI 198

  Rat   186 VTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLV 250
            :.:|.||:.:.:|.|...|:|..|..|.|...:.:.:.:..|.||...|.....:..:.:.||.|
  Fly   199 LGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEV 263

  Rat   251 GLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGK-VP 314
            .||..|.|..|||.|......|:.:.|.|:|.:|||.||||||.:..||..|:.:.|..|.: :|
  Fly   264 LLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELP 328

  Rat   315 PADLKMLCLE-----EDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGA 374
            .:.|..|.|.     :.:||.|.| ..:.|:  |.:.........|....::|.||.::|.....
  Fly   329 ESVLDKLVLANRDKLQQSSESRFP-IREAFK--NFKWRIANCSLCWIVHVLVYYGLSLNVVLLDG 390

  Rat   375 NLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLG 439
            :.|.:|.|.:|||.|..|:.|:.:||.||.|.:....|.:|..|:..||...:...|.:.|..:|
  Fly   391 DKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVG 455

  Rat   440 RMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLG 504
            ::..|...|::....:|:|||.:||..:..||.:...|.:..| ....|.:.:...|.:||....
  Fly   456 KLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP-QTPLLAKYYANAPAMLFAGAA 519

  Rat   505 LTAGAMTLLLPETKGVALPETIEEAENLG-RRKSKAKE 541
            :.:|.:||..|||..|.||.|::||:.:| :::||:|:
  Fly   520 IVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKD 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	159/530 (30%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	117/396 (30%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	159/530 (30%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	116/387 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347302
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960