Protein Alignment Slc22a1 and SLC22A

DIOPT Version :10

• Sequence 1: NP_036829.1
• Gene: Slc22a1 / 24904
• RGDID: 3224
• Length: 556
• Species: Rattus norvegicus
• Sequence 2: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Alignment Length: 558
• Identity: 169/558 - (30%)
• Similarity: 262/558 - (46%)
• Gaps: 45/558 - (8%)

  Rat     3 TVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGH-----YCQNPGVAELSQRC 62
            |:|.:|:.:|:||.||...|||:||.....|...|..||...|..|     .|..||........
  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT 90

  Rat    63 GWSQAEELNYTVPGLGPSDEASFLSQCMRYE----VDWNQSTLDCVDPLSS--LVANRSQLPLGP 121
            .||        :|..|..     |..|.||.    ..||.|    ||..|:  ...|:.     .
  Fly    91 NWS--------IPKNGKD-----LDSCNRYTNSELPQWNHS----VDICSADHFTKNKE-----A 133

  Rat   122 CEHG-WVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTL 185
            |.|. :|:.....:|..:|.:.|.|.||:.:..:..|||.|.|..:.|::|||:||...:.:..:
  Fly   134 CAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGI 198

  Rat   186 VTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLV 250
            :.:|.||:.:.:|.|...|:|..|..|.|...:.:.:.:..|.||...|.....:..:.:.||.|
  Fly   199 LGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEV 263

  Rat   251 GLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGK-VP 314
            .||..|.|..|||.|......|:.:.|.|:|.:|||.||||||.:..||..|:.:.|..|.: :|
  Fly   264 LLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELP 328

  Rat   315 PADLKMLCLE-----EDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGA 374
            .:.|..|.|.     :.:||.|.| ..:.|:  |.:.........|....::|.||.::|.....
  Fly   329 ESVLDKLVLANRDKLQQSSESRFP-IREAFK--NFKWRIANCSLCWIVHVLVYYGLSLNVVLLDG 390

  Rat   375 NLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLG 439
            :.|.:|.|.:|||.|..|:.|:.:||.||.|.:....|.:|..|:..||...:...|.:.|..:|
  Fly   391 DKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVG 455

  Rat   440 RMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLG 504
            ::..|...|::....:|:|||.:||..:..||.:...|.:..| ....|.:.:...|.:||....
  Fly   456 KLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP-QTPLLAKYYANAPAMLFAGAA 519

  Rat   505 LTAGAMTLLLPETKGVALPETIEEAENLG-RRKSKAKE 541
            :.:|.:||..|||..|.||.|::||:.:| :::||:|:
  Fly   520 IVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKD 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	159/530 (30%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	118/397 (30%)