DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a1 and CG4630

DIOPT Version :9

Sequence 1:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	173/580 - (29%)
Similarity:	276/580 - (47%)	Gaps:	63/580 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNP---GVAELSQRCGWSQ 66
            ||:|.::||||.||::.:||:||.....|...:..||...:|.:.|..|   .:.:......|
  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW-- 78

  Rat    67 AEELNYTVPGLGPSDEASFL-SQCMRYEV--DWNQSTLD--CVDPLSSLVANRSQLPLGPCEHGW 126
               ::..||| ..|....|. |.|.|:..  |..:|:.|  ...||....|.........|.. :
  Fly    79 ---VSIAVPG-SWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQ-F 138

  Rat   127 VYDTPGSSIVTEFNLVCGD-AWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVS 190
            ||.:...:||.::.|.|.: .||:....:....|..:|:.:.||:|||:|||...|...:..:::
  Fly   139 VYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALT 203

  Rat   191 GVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGV 255
            ||..|::.||.|.|.|.||..:.:.|.:...:.:..|.||...|..::|:....:.|| ..|.|:
  Fly   204 GVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVG-EALLGL 267

  Rat   256 AYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKM 320
            :..:||||.||||:|:|..:.:.|:|.||||.||||::.|..:|..|:.:.|:.|.:    |:.:
  Fly   268 SVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR----DISV 328

  Rat   321 LCL--------------EEDA--------SEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQ 363
            ..:              |:|.        .:|...:..::.|:..|.....||:.:|...|::|.
  Fly   329 ELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYY 393

  Rat   364 GLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIP--- 425
            ||.::..:...|.||:|....|||.|...:..:.:.|.||...::.|.|:....|:...|:.
  Fly   394 GLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQ 458

  Rat   426 -------------HE---LHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALC 474
                         |.   .:||.|||..:|::|.|....::....||:.||.||:.|:.|.|...
  Fly   459 GDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFA 523

  Rat   475 DLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGR 534
            ..|.:..||:.. |...:..|||:|||.|.|.||.::||||||....||:|:|||..||:
  Fly   524 RFGAMLAPFVPL-LASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALGK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	164/562 (29%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	126/431 (29%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	164/562 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	106/379 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860