Protein Alignment ALPL and Alp5

DIOPT Version :10

• Sequence 1: NP_000469.3
• Gene: ALPL / 249
• HGNCID: 438
• Length: 524
• Species: Homo sapiens
• Sequence 2: NP_650931.1
• Gene: Alp5 / 42482
• FlyBaseID: FBgn0038845
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 504
• Identity: 217/504 - (43%)
• Similarity: 297/504 - (58%)
• Gaps: 52/504 - (10%)

Human    19 VPEKEKDPK------------YWRDQAQETLKYALELQKL----NTNVAKNVIMFLGDGMGVSTV 67
            :||.|:..|            |||.|..:.::     |||    |...|||||:||||||||:|.
  Fly    41 MPEPERHGKAFRVVDGEDTNAYWRQQGVQFVQ-----QKLASEPNKRQAKNVILFLGDGMGVTTT 100

Human    68 TAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSA 132
            :|||.|.|      |||..|..:.|||..|||||:.:..|||||.||||||||||..|||:||:.
  Fly   101 SAARNLLG------GEEKSLSFENFPFTGLSKTYSVDKIVPDSACTATAYLCGVKGQEGTIGVNG 159

Human   133 ATERSRCNT--TQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPE 195
            ...|:.|..  .:...|.||.:||.:|||..|:||||||.||:||..|||.|:|||.:|.|:..:
  Fly   160 QVPRTDCKVMLDESTHVDSIAKWAMEAGKWAGLVTTTRVTHASPSGVYAHIAERDWENDAEVATD 224

Human   196 -ALSQGCKDIAYQLMHNI--RDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWK 257
             ....|..||||||....  ..:.||||||||:.         .:|..::.|.|.|||:|:|
  Fly   225 CGAGSGINDIAYQLARGEVGSKLKVIMGGGRKHF---------VDSSLESWGKRTDGLNLID--- 277

Human   258 SFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYEL-NRNNVTDPSLSEMVVVAIQILR 321
            .||...:::.::....||..:|....|.|||||....:||.: .....:.|:|.:|...||:.:.
  Fly   278 EFKSASENNVYVTTAAELAAVDVTKTDRLLGLFNDDHLQYLMETTTESSQPTLEQMTRKAIEYMS 342

Human   322 KNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFG 386
            :|.:|:||.:||||||..||..:|:.||:|.:|..:||..|..|||.:|||.|||||||||||:.
  Fly   343 QNEQGYFLFIEGGRIDQAHHINQARMALNETIEFSKAIAAAQELTSEDDTLLVVTADHSHVFTYA 407

Human   387 GYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYK----VVGGERENVSMVDYAHNNYQAQSAV 447
            ||:.||:.:||..| ::..|.||:..:.|.|||.|:    ....||::.:.|....::.:..|.|
  Fly   408 GYSYRGSDVFGKTP-VNGHDGKPYMVLSYANGPSYENFYDAETMERKDPTTVVKGDHDDEFPSGV 471

Human   448 PLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGH 496
            |:..::|||:||.|::.||.|||..||:||:.:||:||||:|:|.  ||
  Fly   472 PIDMDSHGGDDVPVYALGPWAHLFTGVYEQSTIPHMMAYASCLGD--GH 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:395188	201/448 (45%)
Alp5	NP_650931.1	alkPPc	85..515	CDD:214515	201/448 (45%)