Protein Alignment ALPL and Alp13

DIOPT Version :10

• Sequence 1: NP_000469.3
• Gene: ALPL / 249
• HGNCID: 438
• Length: 524
• Species: Homo sapiens
• Sequence 2: NP_649978.2
• Gene: Alp13 / 41236
• FlyBaseID: FBgn0037786
• Length: 479
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 132/523 - (25%)
• Similarity: 214/523 - (40%)
• Gaps: 119/523 - (22%)

Human     8 LAIGTCLTNSLVP----------EKEKD-----------------PKYWRDQAQETLKYALELQK 45
            |..||||...:|.          |.|.|                 .|.|.|:..:.|..||..|.
  Fly    23 LVAGTCLITVMVTLLCIGFMTRYEVENDVANVADVDYWKDKVATSQKIWYDKGIDELNEALRPQD 87

Human    46 LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVP-D 109
            |  ...|||.:|:..|:......|.|.........   .|....|:||.:|..|. :.:.|.| .
  Fly    88 L--TYPKNVRIFVIQGIDGRDWAAFRFPTSDASRG---NTNFIWDRFPHLARLKN-SCSQQFPCQ 146

Human   110 SAGTATAYLCGVKANEGTVGVSAATERSRC----NTTQGNEVTSILRWAKDAGKSVGIVTTTRVN 170
            .|..:.|...|:..::      ....:..|    |.|||  ..||||.|:.||...|.|||.|:
  Fly   147 VASVSRALWLGIPLDK------VPDNQQDCGRLFNATQG--PISILRQAQLAGLRTGFVTTQRI- 202

Human   171 HATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNI--RDIDVIMGGGRKY---MYPKN 230
             ..|:.|...:|:.::..|..||..::..||:|||.||:.:.  :.::|::||||:.   :.|..
  Fly   203 -TGPTGAALGNANGNFECDESMPLNSIKSGCQDIAQQLISDETGKFLNVLIGGGRQMLSSLVPNT 266

Human   231 KTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHS-------HFIWNRTELLTLDPHNVDYLLG 288
            |    |:..::......||.:|:..|::.|  .|.|       ..|..|.||.:|:..:.|||:|
  Fly   267 K----YDPVDEMLCESNDGRNLLKDWRNQK--LKESKINRIIFDLIQRRDELESLNSSSFDYLMG 325

Human   289 LFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAV 353
            :...||:.     .|...|||..||..::.:|.|..:|:.|:|| ..|..|..:.:..|.|::.:
  Fly   326 VMANGDLS-----GNSKAPSLKLMVDKSLNVLTKYKQGYLLIVE-QFIPSGIDKREQLQLLNDTL 384

Human   354 EMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNG 418
            .         :|...:||||:|...              |:|:. .|.|.
  Fly   385 V---------NLHKDQDTLTLVLMT--------------NAIYP-KPSLD--------------- 410

Human   419 PGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHV 483
                 |..|.|.:|::....|  :|:|.:..|......|.: :|::||.:.:..||.::.::.|.
  Fly   411 -----VSEETETISLLPEIFN--EAESEIQKRLHQMPSESL-LFAQGPKSSIFQGVRKETFLAHA 467

Human   484 MAY 486
            :::
  Fly   468 ISH 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:395188	115/453 (25%)
Alp13	NP_649978.2	ALP_like	127..472	CDD:474031	107/414 (26%)