Protein Alignment ALPL and Alp2

DIOPT Version :10

• Sequence 1: NP_000469.3
• Gene: ALPL / 249
• HGNCID: 438
• Length: 524
• Species: Homo sapiens
• Sequence 2: NP_611654.1
• Gene: Alp2 / 37539
• FlyBaseID: FBgn0283480
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 246
• Identity: 47/246 - (19%)
• Similarity: 83/246 - (33%)
• Gaps: 68/246 - (27%)

Human    21 CACQIKCRMEGLLHYINPAHAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQS 85
            |.....|.:|.|...:.|.             :||:|.|           .||..|..:|:....
  Fly     8 CLALAACSLEALSVELQPG-------------VKGRLQD-----------RHKRTLVFTSDSATG 48

Human    86 ---------LFTNKENEAQTVFQLDFCEP----DAFDNVLNYIYSSSLFVEKGSLAAVQELGYSL 137
                     |..::.......|:.::..|    |....||..:.:..:..|:|..|..:.
  Fly    49 ILFALSVPLLIPDRNIFLAYNFEANYGMPGKASDFTQGVLKKVDNDQIHPEEGEAAEDKR----- 108

Human   138 GISFLTNIVAKAPQAPFPACPNRKRV--PVE---DDETSSQKRSVI--VCQGRSEVPGKASGPAM 195
              |..|...|....|.|    .||:|  .:|   :......|:.::  :|: .::.|.:.....:
  Fly   109 --SIRTTAAATTATAGF----TRKKVYRMIELNLNRHGYDGKKCILRMICE-LAKHPVRDGNGIV 166

Human   196 QDLSHTARASPSASVKTTISKPHVAKPPEQLHSLPLTEKSWTKDSAAVYAK 246
            .||.... .:||.|....:       |.|..|:    |||..:::.|.|::
  Fly   167 GDLLQLV-FTPSESYNEGL-------PGEFYHA----EKSGKRENCAKYSR 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:395188	42/216 (19%)
Alp2	NP_611654.1	ALP_like	89..525	CDD:474031	28/141 (20%)