Protein Alignment ALPL and Alp6

DIOPT Version :10

• Sequence 1: NP_000469.3
• Gene: ALPL / 249
• HGNCID: 438
• Length: 524
• Species: Homo sapiens
• Sequence 2: NP_610496.1
• Gene: Alp6 / 35981
• FlyBaseID: FBgn0033423
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 224/523 - (42%)
• Similarity: 289/523 - (55%)
• Gaps: 54/523 - (10%)

Human     6 LVLAIGTCLTNSLVPEK-------------------EKDPKYWRDQAQETLKYAL-ELQKLNTNV 50
            |:|.:..||:.|...::                   |:..:||.|:||..|...| |.:...||.
  Fly     7 LLLVLAVCLSGSASGQRDHPRGRSFDAESHPIKYAEEQQTQYWVDKAQAKLLSKLAEQESATTNK 71

Human    51 AKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTAT 115
            |||||:||||||.|.||||.|.|.|    :..|:...|  .||:..|||||..|.||.|||.|||
  Fly    72 AKNVILFLGDGMSVHTVTATRNLLG----DSAEQVYFE--GFPYTGLSKTYCVNRQVADSACTAT 130

Human   116 AYLCGVKANEGTVGVSAATERSRCNTTQGNE--VTSILRWAKDAGKSVGIVTTTRVNHATPSAAY 178
            |||.|||||.||:||:|...|..|:.....|  |.||..||:.|||..|:|||.||.||:|:..|
  Fly   131 AYLGGVKANYGTIGVNANVSRYSCDGAANEEDRVLSIAHWAQAAGKDAGLVTTARVTHASPAGVY 195

Human   179 AHSADRDWYSD-----NEMPPEALSQGCKDIAYQLMHNI--RDIDVIMGGGRKYMYPKNKTDVEY 236
            ||.|||:|.:|     .|..||...    |||.||:...  :.:.||:||||     ||..|...
  Fly   196 AHIADRNWENDWEVANRECDPEQTI----DIARQLVEQPVGQQLKVILGGGR-----KNFIDATV 251

Human   237 ESDEKARGTRLDGLDLVDTWKSFKPRYKHS-HFIWNRTELLTLDPHNVDYLLGLFEPGDMQY--- 297
            ..:|...|.|.||..|:.:|...|.....| .::|:|..|..:|..|.|||||||....:.|
  Fly   252 NDEEGYPGKRTDGRHLIRSWLDQKKEANVSAKYVWSRKGLSLVDLENTDYLLGLFANDHLPYNGD 316

Human   298 -ELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQ 361
             :..|:.:.||||||:...||.:|.:|.|||||.|||.|||..||:..||::|.:..|..||:.:
  Fly   317 RDRKRSQLADPSLSELTEAAITVLSRNDKGFFLFVEGARIDMAHHDTFAKRSLEDTAEFARAVQK 381

Human   362 AGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGG 426
            |..|||.:|||.||||||:||.:..||..|...|.||| .|:| |..|:|.:.|.|||||.....
  Fly   382 ARELTSEDDTLIVVTADHAHVMSINGYPYRDQEITGLA-QLAD-DNLPYTILSYANGPGYYSGYN 444

Human   427 ERENVSMVD---YAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAA 488
            ..|..:::.   .|.::||..:..||..|||||:||||::.||.|....|.:||:.:|.:||.||
  Fly   445 RAEGRALLKEKLVADSDYQYPTLAPLDAETHGGDDVAVYASGPYAQYFSGNYEQSNIPALMARAA 509

Human   489 CIG 491
            .||
  Fly   510 GIG 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:395188	206/455 (45%)
Alp6	NP_610496.1	alkPPc	73..512	CDD:214515	205/455 (45%)