DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc6a3 and List

DIOPT Version :9

Sequence 1:	NP_036826.1	Gene:	Slc6a3 / 24898	RGDID:	3715	Length:	619	Species:	Rattus norvegicus
Sequence 2:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	206/563 - (36%)
Similarity:	313/563 - (55%)	Gaps:	22/563 - (3%)

- Green bases have known domain annotations that are detailed below.

  Rat    42 LTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFM 106
            :|...:....:.|.| :..|.|...::||.|.|..:|.|.|:|||||:.::||||.|::|||:.:
  Fly     1 MTQLEISKKSEKPAE-KPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIAL 64

  Rat   107 VIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSF 171
            ::.|.|::|:|::||||...|....:.:.|:||||....:|.:.....:|:.|:|..|.::.:||
  Fly    65 LVIGRPVYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASF 129

  Rat   172 TMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDD-LGPP 235
            ..:|||..|..:|.: :|.|.:|.|||..:        :||..||||.:  ||:...||: |..|
  Fly   130 GSELPWSRCWESWGT-DCHDGNAQNSSGKM--------SPAQLYFEREI--LHEVPNIDNGLSLP 183

  Rat   236 RWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD 300
            .|||.|||.:..:::...|.:|:|:|||..:.....|||||..||||.||||||:|||..:....
  Fly   184 NWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQ 248

  Rat   301 FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFS 365
            :..|....||..|.|||.|||.:.||.||.::|||.|..|.|.|.:|.|:::|.:|..:|.:.|.
  Fly   249 WRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFG 313

  Rat   366 FLGYMAQKHNVP-IRDVATDGPGLIFIIYPEAIATLP-LSSAWAAVFFLMLLTLGIDSAMGGMES 428
            .||.:|::...| |..|...|.||.||.||||||... :...:|.:|||||..|||.|.:|....
  Fly   314 ILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSC 378

  Rat   429 VITGLVDEFQLLHRHRELFTL--GIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEA 491
            ::..:.|:|.|  |...::.|  |:.:..|.:|:..:|.||.::..|:|.:....:.|...:.|.
  Fly   379 ILRVIRDQFGL--RSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGEL 441

  Rat   492 IGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWA 556
            :.|||.|||.:|.:|||.|.|.....||||||:.::|..:..|::..::......|....:|..|
  Fly   442 VAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLA 506

  Rat   557 NALGWIIATSSMAMVP---IYATYKFCSLPGSFREKLAYAITP 596
            :..|..:||..:..:|   |||.||.....|||.:::..|..|
  Fly   507 HVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKP 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	203/545 (37%)
Slc6a3	NP_036826.1	Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		12/31 (39%)
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	186/482 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820