DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc6a3 and CG8850

DIOPT Version :9

Sequence 1:	NP_036826.1	Gene:	Slc6a3 / 24898	RGDID:	3715	Length:	619	Species:	Rattus norvegicus
Sequence 2:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	195/569 - (34%)
Similarity:	305/569 - (53%)	Gaps:	17/569 - (2%)

- Green bases have known domain annotations that are detailed below.

  Rat    33 LVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGA 97
            ::....|.:||    ||.......:.:|:.||:.::||.|.|..:|.|.||||||::..:|||||
  Fly    34 VIYSAEGEELT----INCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGA 94

  Rat    98 FLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAW 162
            ||:||::.:::.|.|::|:|:.:|||:..|....:.:.|:::|:.:..:..:.....:|..|:|.
  Fly    95 FLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMAL 159

  Rat   163 ALHYFFSSFTMDLPWIHCNNTWNSPNC--SDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQ 225
            .:.|..:||:..|||.:|...|.. :|  :.|.|:|.|     :...|.:.|..:|.:.||...:
  Fly   160 TIRYLVASFSEVLPWTYCLVEWGK-SCVATGATAANDS-----SIVQGVSSAELFFTQTVLREPE 218

  Rat   226 SRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAM 290
            |...:.||.|.|.|..||:...|::...|.||:::|||..:..|..|||::..||:|.||||||.
  Fly   219 SLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAW 283

  Rat   291 DGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLT 355
            .||..:|...:.:|....||..|.||:.|||.:.||.|:.::|:|.|..|.::|.||.|:|:|||
  Fly   284 QGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLT 348

  Rat   356 SFSSGFVVFSFLGYMAQKHNV-PIRDVATDGPGLIFIIYPEAIATLP-LSSAWAAVFFLMLLTLG 418
            |..:|.::|..||.:|.:.|. .|..|...|.||.||.||||||... |...:|.:||.|||.||
  Fly   349 SILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLG 413

  Rat   419 IDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSI 483
            |.|.:|...:|:..:.|.|  .|....|..:...:..||..|..:|.||.:|..|:|.:......
  Fly   414 IGSNIGMASAVVNVVKDRF--THLPHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIA 476

  Rat   484 LFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYG 548
            |...:.|.:.|.|.|||::...||:.|...:.:.|||:||.:|:|..:..|:|..:.::.|..|.
  Fly   477 LVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYR 541

  Rat   549 AYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPG-SFREKLAYAITP 596
            ...:|......||||....:..:|.:|.......|| :|..|...|:.|
  Fly   542 GVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQP 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	190/542 (35%)
Slc6a3	NP_036826.1	Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		9/29 (31%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	174/481 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820