DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbxas1 and Cyp317a1

DIOPT Version :9

Sequence 1:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus
Sequence 2:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	140/543 - (25%)
Similarity:	246/543 - (45%)	Gaps:	78/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Rat     3 VLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPS---PFVGNLM---FFRQ 61
            |||||               |||.:...|....:   |.|.|.|..|.   |.:..:|   ...:
  Fly    12 VLGLL---------------VLLIIAARYQRDYW---RYLDIPHERPKKLWPIIRQIMTQTLSTE 58

  Rat    62 GFWESHLE-LRERY---GPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGL------E 116
            .....|.. :.:::   ||.||:|...:...:|.|.::|:::::::|.||::|   ||      :
  Fly    59 AMKAEHYSAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDR---GLYCNQKSD 120

  Rat   117 PKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAAS--GDAFDIQ 179
            |  ::..:..||...|:|:|..|..:...::::.:...:.:..|.||..:..:..|  .....||
  Fly   121 P--LSGDLYALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQ 183

  Rat   180 RCYCCFTTNVVASVAFGIEVNSQDA-PEDPFVQHCQRVFAFSTPRPLLAL-ILSFPSIMVPLARI 242
            :....:..:.:|...||:....:.. |.:.|.|..:..........|:.| ::.||:....|...
  Fly   184 KIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRMR 248

  Rat   243 LPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSA 307
            ...|..:|   :|..|:.:::  ..::|:.:.:.|:||:::|         |:|.:.:|....:.
  Fly   249 RTPKQAEE---YFIKLLTSIV--EQRETSGKPQKDYLQLLID---------VKALEFITHQYEAD 299

  Rat   308 ECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVD 372
            :.:|...|             :|:|..|.:||.||:|.|.||||::.|.||.|||.|.|:.:||.
  Fly   300 KELGAHLQ-------------NELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVK 351

  Rat   373 LFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQH----IPAGSVLEI 433
            ..:|:|.........:.|.::..|:.|||||:|......|....|..| ..|    :.....|.|
  Fly   352 KAIERHDGHITHEGIKSLSFMGQVINETLRMHPITPYILRRTLNDYAV-PDHPKYILVKELFLII 415

  Rat   434 AVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLH 498
            ...|:||||:.:|:||.|.|:|::......|:..|:..||.|.|||:|::...|.::|.|..:|.
  Fly   416 PTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLS 480

  Rat   499 KFRFEACPETQVPL-QLESKSAL 520
            ::.|..  .|:.|| .||...||
  Fly   481 EYEFSL--NTRKPLINLEDGIAL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	127/499 (25%)
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	115/459 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820