DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbxas1 and Cyp6a20

DIOPT Version :9

Sequence 1:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus
Sequence 2:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	154/542 - (28%)
Similarity:	269/542 - (49%)	Gaps:	73/542 - (13%)

- Green bases have known domain annotations that are detailed below.

  Rat    16 VTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGN------LMFFRQGFWESHLELRERY 74
            |.:.|.:.::..:.||....|:..::.||.|.||....||      .:.|...|..::.:||.:.
  Fly     3 VMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADIFKRTYNKLRNKT 67

  Rat    75 -GPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGL------EPKLIADSVLMLRDRRW 132
             ||..|:|:..:..:|::|.|..|.||:..|..|.:|   |:      :|  ::.:::.:..::|
  Fly    68 DGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDR---GVFHNERDDP--LSANLVNIDGQKW 127

  Rat   133 EEVRGALMSAFSPEKLNEMTP-LISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFG 196
            :.:|..|...|:..|:..|.| :::...||:....:.::|..|:.:|......||.:|:.|.|||
  Fly   128 KTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSCAFG 192

  Rat   197 IEVNSQDAPEDPFVQHCQRVFAFSTPR---PLLALILSFPSIMVPLARILPNKNRDELNGFFNTL 258
            ::.:|...|:..|||  ....|.:..|   .:..|:...|.:   .|::.......|:..|:..:
  Fly   193 LDCHSLSDPKAKFVQ--MGTTAITERRHGKSMDLLLFGAPEL---AAKLRMKATVQEVEDFYMNI 252

  Rat   259 IRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTA 323
            ||:.:..|.|...  :|.||:.|:::.:....:                   ||         ..
  Fly   253 IRDTVDYRVKNNV--KRHDFVDMLIEMKLKFDN-------------------GD---------KE 287

  Rat   324 KPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAP-EYCNLQ 387
            ..||.:|||.|||:|.:||.|.::.|:.|..|.||.|.:.|::|..|::..:::|... :|.:::
  Fly   288 NGLTFNEIAAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMR 352

  Rat   388 EGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQH------IPAGSVLEIAVGALHHDPEHWP 446
            | :.||:.|:.||:|..|......|.|.|..    ||      |..|:.:.:...|:|||||.:|
  Fly   353 E-MTYLEKVIDETMRKRPVVGHLIRVATQHY----QHTNPKYNIEKGTGVIVPTLAIHHDPEFYP 412

  Rat   447 NPETFDPERFTAEARLQQKP-FTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACP-ETQ 509
            .||.|.||||. |.::||:| .|:||||.|||:|:|:|.|.:.|.:.:..::|.|:||..| :|.
  Fly   413 EPEKFIPERFD-EDQVQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTV 476

  Rat   510 VPLQLESKS-ALCPKNGVYVKI 530
            |||:..:.. .|..|.|:::|:
  Fly   477 VPLEYRTDDFLLSSKGGIHLKV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	145/509 (28%)
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	146/509 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770