DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbxas1 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	148/532 - (27%)
Similarity:	254/532 - (47%)	Gaps:	49/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    15 VVTVTLSVVLL----ALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR-----QGFWESHLEL 70
            |.:|.|::|::    .||||  ..|....:.|.|...||...:|:|...:     ...|..:...
  Fly     3 VYSVLLAIVVVLVGYLLLKW--RRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNK 65

  Rat    71 RERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNR-MASGLEPKLIADSVLMLRDRRWEE 134
            ....||..|:|..:|..|::.|..:.|.:|::.|:.|::| .....|...::..:.:|..::|:.
  Fly    66 FRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLLDGQKWKS 130

  Rat   135 VRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEV 199
            :|..|...|:..|:..|.|.:.:.....:.....:.......:::.....|||:|:.:.|||||.
  Fly   131 MRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGIEC 195

  Rat   200 NSQDAPEDPFVQHCQRVFAFSTPRPL-LALILSFPSIMVPLARILPNK-NRDELNGFFNTLIRNV 262
            :|...||..|....:|........|: :|.|.||.:    |||.|..| ..:|...||..::|..
  Fly   196 SSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQN----LARRLHMKITLEEAEHFFLRIVRET 256

  Rat   263 IALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLT 327
            :|.|:|...  ||.||:..::|.:.|              .|:.:|           :..:..||
  Fly   257 VAFREKNNI--RRNDFMDQLIDLKNS--------------PLTKSE-----------SGESVNLT 294

  Rat   328 VDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPY 392
            ::|:|.|||:|..||.|.::.|:.|..|.||.|.:.|:|:.||....:.|:.........:.:.|
  Fly   295 IEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVY 359

  Rat   393 LDMVVAETLRMYPPAFRFTREAAQDCEVLGQH---IPAGSVLEIAVGALHHDPEHWPNPETFDPE 454
            ||.|::||||:|.......||..:|.||.|..   |..|..:.|..||:|.|.:.:.||.||:|:
  Fly   360 LDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPD 424

  Rat   455 RFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSA 519
            .|:.|...::....:||||.|||:|:|:|.|.:..:..|..::::|:|..|.:|.:|:....|:.
  Fly   425 NFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTF 489

  Rat   520 L-CPKNGVYVKI 530
            | ..:.|:::|:
  Fly   490 LISSETGIFLKV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	136/494 (28%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	136/494 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770