DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbxas1 and Cyp6a23

DIOPT Version :9

Sequence 1:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus
Sequence 2:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	156/535 - (29%)
Similarity:	256/535 - (47%)	Gaps:	64/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    18 VTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNL----------MFFRQGFWESHLELRE 72
            :||..:|::||.:.:.......::.||.|..|.|..||:          |.||    :.:.:.:.
  Fly     5 LTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFR----DYYTKYKR 65

  Rat    73 RYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIAD----SVLMLRDRRWE 133
            ...|..|:|.......||:|.:::|.||:::|::|.||   |:....|.|    ::..:..::|.
  Fly    66 SVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENR---GIFYNEIDDPLSATLFSIEGQKWR 127

  Rat   134 EVRGALMSAFSPEKLNEMTPLISQACELL--LSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFG 196
            .:|..|...|:..|:..|.|:|.:..|.:  :...|.:...|...:|......:|.:|:.:.|||
  Fly   128 HLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFG 192

  Rat   197 IEVNSQDAPEDPFVQHCQRVFAFSTPRPLL-ALILSFPSIMVPLARILPNK-NRDELNGFFNTLI 259
            :..||...|...||...:|.........|| .||..||.    |:|.|..| |..::..|:.:::
  Fly   193 LNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPK----LSRRLRLKLNVQDVEDFYTSIV 253

  Rat   260 RNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAK 324
            ||.|..|.:  ..|:|.||:..:::                   :...|..|         :|..
  Fly   254 RNTIDYRLR--TNEKRHDFMDSLIE-------------------MYEKEQAG---------NTED 288

  Rat   325 PLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAP-EYCNLQE 388
            .|:.:||..|||:|.:||.|.::.|:.|..|.||...:.|::|..|::..:.||... .|..::|
  Fly   289 GLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKE 353

  Rat   389 GLPYLDMVVAETLRMYPPAFRFTREAAQDC--EVLGQHIPAGSVLEIAVGALHHDPEHWPNPETF 451
             :.||:.||.||||.||.....||....|.  |.....|..|:.:.|....:|:|||.:|.||.|
  Fly   354 -MKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKF 417

  Rat   452 DPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLES 516
            .|||||.||...:...|:||||.|||:|:|:|.||:...:.|..::..::|....|||:|::...
  Fly   418 KPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVV 482

  Rat   517 KS-ALCPKNGVYVKI 530
            || .|..:||:::|:
  Fly   483 KSILLSAENGIHLKV 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	147/504 (29%)
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	147/500 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770