DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbxas1 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	155/535 - (28%)
Similarity:	259/535 - (48%)	Gaps:	67/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat    17 TVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR-QGFWESHLELRERY------ 74
            |:.|...||:.|..|....|:.....||....|....|:  ||| |....|.| |:|.|
  Fly     4 TLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGH--FFRLQSVHYSEL-LQETYDAFRGS 65

  Rat    75 GPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGAL 139
            ..:.|.|:..|...|:.|.|::|.||:.:|:||.:|.:...:|  :..::..|:...|..:|..|
  Fly    66 AKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHGDP--LTANLFNLQGEEWRNLRTKL 128

  Rat   140 MSAFSPEKLNEMTPLISQACELLLSHLKHSAAS-GDAFDIQRCYCCFTTNVVASVAFGIEVNSQD 203
            ...|:..|:..|...:|...:.|.........| |...::......:||:|:.|.|||.|.:|..
  Fly   129 SPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAFGTECSSLR 193

  Rat   204 APEDPFVQHCQRVFAFSTPRPL------LALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNV 262
            .|:..|.|..:|:|..|. |.:      :..:.|...:.:|: |||    ..::..|||.::|..
  Fly   194 EPQAEFRQVGRRIFRNSN-RSIRWRIFKMTYLSSLAKLGLPV-RIL----HPDITKFFNRIVRET 252

  Rat   263 IALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLT 327
            :.||:::..  ||.||:.::||.:|.                                ...|.||
  Fly   253 VELRERENI--RRNDFMDLLLDLRRQ--------------------------------ENGKGLT 283

  Rat   328 VDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPY 392
            ::::|.|||:|.:||.|.:::.:|:..:.||.:.:.|::|..|::..:.||....|..:.| :||
  Fly   284 MEQMAAQAFVFFVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMME-MPY 347

  Rat   393 LDMVVAETLRMYPPAFRFTREAAQDCEVLGQH------IPAGSVLEIAVGALHHDPEHWPNPETF 451
            ||..:.||||.||.....||.|::|.|:....      :..|:.:.|.|.|:|:|||.:|.|..|
  Fly   348 LDQTITETLRKYPALSSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEF 412

  Rat   452 DPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLES 516
            .||||..:|..::.|..:|.||.|||:|:|:|.|.:.||:.|:.:|.:|||...|.:...|::..
  Fly   413 RPERFAPDACRERHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTK 477

  Rat   517 KS-ALCPKNGVYVKI 530
            :: .|.|.:||.:::
  Fly   478 RNLILLPSDGVRLQV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	146/503 (29%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	146/505 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870