DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FRZB and smo

DIOPT Version :9

Sequence 1:	NP_001454.2	Gene:	FRZB / 2487	HGNCID:	3959	Length:	325	Species:	Homo sapiens
Sequence 2:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster

Alignment Length:	175	Identity:	40/175 - (22%)
Similarity:	60/175 - (34%)	Gaps:	41/175 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    31 RAAACEPV--RIPLC--KSLPWNMTKMP-NHLHHSTQANAIL----AIEQFEGLLGTHCSPDLLF 86
            |.|.|.|.  ....|  ..||:.::.:. ...|...:.|..|    |::..     ..|...:..
  Fly    86 RRARCYPTSNATNTCFGSKLPYELSSLDLTDFHTEKELNDKLNDYYALKHV-----PKCWAAIQP 145

Human    87 FLCAMYAPIC-TIDFQHEPIKPCKSVCERARQGCEPILIKYRHS-WPENLACEE----------- 138
            ||||::.|.| .|:.:.....|...:|   |...||..|.|..: :|:.|.|.|
  Fly   146 FLCAVFKPKCEKINGEDMVYLPSYEMC---RITMEPCRILYNTTFFPKFLRCNETLFPTKCTNGA 207

Human   139 --LPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCK 181
              :.....|.|:||..         |.|:|.....|......:||
  Fly   208 RGMKFNGTGQCLSPLV---------PTDTSASYYPGIEGCGVRCK 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FRZB	NP_001454.2	CRD_SFRP3	32..157	CDD:143550	33/148 (22%)
		NTR_Sfrp3_like	188..297	CDD:239636
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	32/142 (23%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810