DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FRZB and frzb

DIOPT Version :9

Sequence 1:	NP_001454.2	Gene:	FRZB / 2487	HGNCID:	3959	Length:	325	Species:	Homo sapiens
Sequence 2:	NP_571018.1	Gene:	frzb / 30119	ZFINID:	ZDB-GENE-990715-1	Length:	315	Species:	Danio rerio

Alignment Length:	293	Identity:	209/293 - (71%)
Similarity:	247/293 - (84%)	Gaps:	19/293 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    16 LLALAALCLLRVP-GARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTH 79
            :..||..|||.:| |..||:|||:|||:|||:|||||||||||||||||||:||||||||||||.
Zfish    11 ICVLAFACLLEIPRGTGAASCEPIRIPMCKSMPWNMTKMPNHLHHSTQANAVLAIEQFEGLLGTQ 75

Human    80 CSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDR 144
            ||.||||||||||||||||||||:||||||||||||:.||||::.:|.|:|||:|||||||||||
Zfish    76 CSADLLFFLCAMYAPICTIDFQHDPIKPCKSVCERAKCGCEPVMKRYNHTWPESLACEELPVYDR 140

Human   145 GVCISPEAIVTADG-----------------ADFPMDSSNGNCRGASSERCKCKPIRATQKTYFR 192
            ||||||||||.|:|                 .||||||.|.||:|| ::|||||.::..||||.:
Zfish   141 GVCISPEAIVKAEGPDNSYYQDPAKCNPEGNPDFPMDSHNTNCKGA-NDRCKCKSVKFNQKTYSK 204

Human   193 NNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIM 257
            |||||||||:||||:.:.||::|:|||||:|||||||||||||.||.:||||||||..|:|||||
Zfish   205 NNYNYVIRARVKEIRIRNHDLSAIVEVKEVLKSSLVNIPRDTVTLYYNSGCLCPPLTANDEYIIM 269

Human   258 GYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWD 290
            |||:||||||||::.|||:|||:::|:||||||
Zfish   270 GYENEERSRLLLIDRSIAQKWKEKIGRKVKRWD 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FRZB	NP_001454.2	CRD_SFRP3	32..157	CDD:143550	106/124 (85%)
		NTR_Sfrp3_like	188..297	CDD:239636	77/103 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325
frzb	NP_571018.1	CRD_SFRP3	28..153	CDD:143550	106/124 (85%)
frzb	NP_571018.1	NTR_Sfrp3_like	200..310	CDD:239636	77/103 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194323884
Domainoid	1	1.000	214	1.000	Domainoid score	I11788
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1126
Inparanoid	1	1.050	450	1.000	Inparanoid score	I7184
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50423
OrthoDB	1	1.010	-	-		D1339129at2759
OrthoFinder	1	1.000	-	-		FOG0010299
OrthoInspector	1	1.000	-	-		oto44944
orthoMCL	1	0.900	-	-		OOG6_113736
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10867
SonicParanoid	1	1.000	-	-		X7712
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	18	18.340