Protein Alignment Pgc and cathD

DIOPT Version :10

• Sequence 1: NP_579818.1
• Gene: Pgc / 24864
• RGDID: 3943
• Length: 392
• Species: Rattus norvegicus
• Sequence 2: NP_652013.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Alignment Length: 403
• Identity: 168/403 - (41%)
• Similarity: 227/403 - (56%)
• Gaps: 36/403 - (8%)

  Rat     6 VALLCLPLLEAS-----------LLRVPLRKMKSIRETMKEQGVLKDFLKTHKYDPGQKYHFGNF 59
            ||||.:..|.|:           ||||||.|.:|.|....:.|.....|:. :|..|.
  Fly     4 VALLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQQLRI-RYGGGD------- 60

  Rat    60 GDYSVLYEPMA-YMDASYFGEISIGTPPQNFLVLFDTGSSNLWVSSVYCQ--SEACTTHARFNPS 121
                 :.||:: ||||.|:|.|:||:|||||.|:||||||||||.|..|.  :.||..|.:::.|
  Fly    61 -----VPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDAS 120

  Rat   122 KSSTYYTEGQTFSLQYGTGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLA 186
            ||.||...|..|::|||:|||:|:...||:::..:.:.:|.|..:.:|||..||.|:||||:||.
  Fly   121 KSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLG 185

  Rat   187 YPGLSSGGATTALQGMLGEGALSQPLFGVYLGSQQGS-NGGQIVFGGVDKNLYTGEITWVPVTQE 250
            |..:|..........|..:|.:|.|:|..||.....| .||:|:|||.|.|.||||.|::|||::
  Fly   186 YNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRK 250

  Rat   251 LYWQITIDDFLIGDQASGWCSSQGCQGIVDTGTSLLVMPAQYLSELLQTIGAQEGEYGEYFVSCD 315
            .||||.:|...|||..  .|.. |||.|.||||||:..|.:..:.:.|.||......|:|.||||
  Fly   251 AYWQIKMDAASIGDLQ--LCKG-GCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCD 312

  Rat   316 SVSSLPTLSFVLNGVQFPLSPSSYIIQ----EDNFCMVGLESISLTSESGQPLWILGDVFLRSYY 376
            .:..||.:.|||.|..|.|....||::    ....|:.|...:.:...:| |||||||||:..||
  Fly   313 LIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNG-PLWILGDVFIGKYY 376

  Rat   377 AIFDMGNNKVGLA 389
            ..|||||::||.|
  Fly   377 TEFDMGNDRVGFA 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgc	NP_579818.1	A1_Propeptide	20..46	CDD:462326	9/25 (36%)
		pepsin_retropepsin_like	73..391	CDD:472175	145/324 (45%)
cathD	NP_652013.1	A1_Propeptide	29..56	CDD:462326	9/27 (33%)
		pepsin_retropepsin_like	62..389	CDD:472175	148/330 (45%)