Protein Alignment Ugt1a1 and Ugt36A1

DIOPT Version :10

• Sequence 1: NP_036815.1
• Gene: Ugt1a1 / 24861
• RGDID: 3935
• Length: 535
• Species: Rattus norvegicus
• Sequence 2: NP_524686.3
• Gene: Ugt36A1 / 44058
• FlyBaseID: FBgn0015663
• Length: 537
• Species: Drosophila melanogaster
• Alignment Length: 579
• Identity: 155/579 - (26%)
• Similarity: 267/579 - (46%)
• Gaps: 99/579 - (17%)

  Rat     1 MSVVCRSSCSLLLLPCLLLCVLG-PSASHAGKLL-VIPIDG-SHWLSMLGVIQQLQQKGHEVVVI 62
            |:...||.    :|..:||.:|| |....||.:| |.|..| ||:..::.::.:|..:||::.||
  Fly     1 MTTCLRSG----VLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI 61

  Rat    63 A----PEASIHIKEGSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSS 123
            :    |:|      |::....:..:....|:.::..:.|             |..|.:...|...
  Fly    62 SYVKNPQA------GAYPNYEELLISAPGEDQSSTTINL-------------VPLTEHTPTRSLG 107

  Rat   124 MLL-----------SGCSHLLHNAEFMASLEQSH---FDALLTDPF-LPCGSIVAQYLSLPAV-- 171
            :|:           ..|.||..:.....::|:..   :|.|||:.| ..|...:|:.|:||.:
  Fly   108 VLIREYVDLHEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGL 172

  Rat   172 -------YFLNALPCSLDLEATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVY 229
                   |:.:    .:||..|  ||   ::.........::|:.:|:.|.:.|....||    |
  Fly   173 STCALMPYYYD----RIDLPDT--PA---FIQSEFVGFAGQLNWHERLLNFVQAKLLKFL----Y 224

  Rat   230 SPYGSLA-TEILQK----EVTVKDLLSPASIWLMRNDFVKDY----PRPIMPNMVFIGGINCLQK 285
            ..:.:.| .|:::|    ||.|:::....:.::..|   :.|    .||.....|.|||:: :.|
  Fly   225 KYHSNRADNELVRKYLGVEVDVEEVARTQTAFIFGN---QHYSLMGSRPQSLQFVEIGGVH-ITK 285

  Rat   286 KA---LSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTR-P 344
            ||   |.|....::|.|.| |::..|.||||  |.|.|.|...|.|.|...|..::|::.... |
  Fly   286 KAEQELPQNIANFLNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETP 349

  Rat   345 SNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETR 409
            ...|...:.|||.||..||.|||.:.|.:|.|..|..|.:..|.|:::.|::|||..||..::.|
  Fly   350 DTDASKFLFVKWAPQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNR 414

  Rat   410 GAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHK--G 472
            |.|:.|:..::|..:|:.||..:..| ||.:..:.:|.:..:|...||:.|::.||:|:.:.  .
  Fly   415 GMGLKLDYQDITVPNLKKALAELSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIA 478

  Rat   473 APHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHK 531
            |..|:....:|..:.|||||.:..:|   |.::.::...| |.|:     :...|.:||
  Fly   479 ARLLQSPGIELNGFVYHSLDSVALIL---LPLILLILVLC-YLCK-----RNPSKLAHK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	142/542 (26%)
Ugt36A1	NP_524686.3	GT1_Gtf-like	28..469	CDD:340817	125/478 (26%)