DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tp53 and p53

DIOPT Version :9

Sequence 1:	NP_112251.2	Gene:	Tp53 / 24842	RGDID:	3889	Length:	391	Species:	Rattus norvegicus
Sequence 2:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	248	Identity:	64/248 - (25%)
Similarity:	109/248 - (43%)	Gaps:	26/248 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat    92 SSSVPSQKTYQ-GNYGFHLGFLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPP-PGTR 154
            ::::|..:.:. |.|.|.:  :.....|| :..|||.||||:.::.|...|.:...|..| ....
  Fly   187 ANTLPKLENHNIGGYCFSM--VLDEPPKS-LWMYSIPLNKLYIRMNKAFNVDVQFKSKMPIQPLN 248

  Rat   155 VRAMAIYKKSQHMTEVVRRCPHHERCS--DGDGLAPPQHLIRVEGNPYAEYLDDRQ----TFRHS 213
            :|....:  |..::..|.||.:|....  ..:.....:.|:|.| ||.:.|..:.|    :.|.|
  Fly   249 LRVFLCF--SNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSE-NPNSVYCGNAQGKGISERFS 310

  Rat   214 VVVPY----EPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCA 274
            ||||.    .....|....|:.:|::|.:||:|   |:....:..||.:.|:::|:....|::|.
  Fly   311 VVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG---RKETSLVFCLEKACGDIVGQHVIHVKICT 372

  Rat   275 CPGRDRRTEEENFR-KKEEHCPEL----PPGSAKRALPTSTSSSPQQKKKPLD 322
            ||.|||..:|.... ||.:..||.    .|...:|.:...|..:.....:..|
  Fly   373 CPKRDRIQDERQLNSKKRKSVPEAAEEDEPSKVRRCIAIKTEDTESNDSRDCD 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tp53	NP_112251.2	Interaction with CCAR2. /evidence=ECO:0000250\|UniProtKB:P04637	1..318		63/242 (26%)
		Transcription activation (acidic)	1..47
		P53_TAD	5..27	CDD:285732
		Interaction with WWOX. /evidence=ECO:0000250	64..108		3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..90
		P53	93..287	CDD:279242	56/205 (27%)
		Interaction with HIPK1. /evidence=ECO:0000250	98..368		63/242 (26%)
		Required for interaction with ZNF385A. /evidence=ECO:0000250	98..298		59/216 (27%)
		Required for interaction with FBXO42. /evidence=ECO:0000250	111..234		34/133 (26%)
		Interaction with AXIN1. /evidence=ECO:0000250	114..290		52/187 (28%)
		Interaction with E4F1. /evidence=ECO:0000250	254..292		14/38 (37%)
		Interaction with DNA. /evidence=ECO:0000250	271..278		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..324		9/47 (19%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	303..319		2/15 (13%)
		Interaction with HIPK2. /evidence=ECO:0000250	317..358		1/6 (17%)
		P53_tetramer	317..356	CDD:285011	1/6 (17%)
		Oligomerization	323..354		64/248 (26%)
		Nuclear export signal. /evidence=ECO:0000250	337..348
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..391
		Interaction with USP7. /evidence=ECO:0000250	357..361
		Basic (repression of DNA-binding)	366..385
		[KR]-[STA]-K motif	368..370
p53	NP_996267.1	P53	203..383	CDD:176262	52/188 (28%)
p53	NP_996267.1	P53_C	429..495	CDD:288471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340688
Domainoid	1	1.000	65	1.000	Domainoid score	I9777
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002925
OrthoInspector	1	1.000	-	-		otm45413
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11447
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6184
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.900