Protein Alignment FRG1 and FRG1

DIOPT Version :10

• Sequence 1: NP_004468.1
• Gene: FRG1 / 2483
• HGNCID: 3954
• Length: 258
• Species: Homo sapiens
• Sequence 2: NP_649202.1
• Gene: FRG1 / 40228
• FlyBaseID: FBgn0036964
• Length: 262
• Species: Drosophila melanogaster
• Alignment Length: 270
• Identity: 130/270 - (48%)
• Similarity: 173/270 - (64%)
• Gaps: 20/270 - (7%)

Human     1 MAEYSYVKSTKLVLKGTKTKSKKKKSKDKKRKREEDEE---------TQLDIV--GIWWTVTNFG 54
            |::|.:.:..||||||.|.|      |.||||:|:||.         ...|.|  |.||......
  Fly     1 MSDYDHARIKKLVLKGEKLK------KSKKRKKEKDEAGSSKKAKVVVDEDAVKHGGWWAAKTAA 59

Human    55 EISGTIAIEMDKGTYIHALDNGLFTLGAPHKEVDEGPSPPEQFTAVKLSDSRIALKSGYGKYLGI 119
            :|:||::||....:|:.|:|||||||||||...| ||.|.|.|||..::|.::|.||||||||.|
  Fly    60 DITGTVSIEFGDRSYLKAMDNGLFTLGAPHNAGD-GPDPEEIFTAFPINDRKVAFKSGYGKYLKI 123

Human   120 NSDGLVVGRSDAIGPREQWEPVFQNGKMALLASNSCFIRCNEAGD-IEAKSKTAGEEEMIKIRSC 183
            ..||:|.|||:|:|..|||||||:..:||||:....|:..:...| ..|..|..|:.|:.|:||.
  Fly   124 EKDGMVTGRSEAVGGMEQWEPVFEEQRMALLSETGHFMSIDPQDDACVALRKKVGQHEICKVRSN 188

Human   184 AERETKKKDDIPEEDKGNVKQCEINYVKKFQSFQDHKLKISKEDSKILKKARKDGFLHETLLDRR 248
            |.|:. ..|..|:|:||::.:.|.|||||||.|||.|::|::.|.|.|::|:..|.|||||||||
  Fly   189 ASRDV-VIDTEPKEEKGDLGEVEKNYVKKFQKFQDKKMRINQNDVKELEQAKAQGSLHETLLDRR 252

Human   249 AKLKADRYCK 258
            :|:|||||||
  Fly   253 SKMKADRYCK 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRG1	NP_004468.1	Nuclear localization signal. /evidence=ECO:0000255	22..32		3/9 (33%)
		FRG1	67..256	CDD:368803	98/189 (52%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	235..251		10/15 (67%)
FRG1	NP_649202.1	FRG1	72..260	CDD:368803	101/188 (54%)