Protein Alignment FRG1 and frg-1

DIOPT Version :10

• Sequence 1: NP_004468.1
• Gene: FRG1 / 2483
• HGNCID: 3954
• Length: 258
• Species: Homo sapiens
• Sequence 2: NP_499696.2
• Gene: frg-1 / 176719
• WormBaseID: WBGene00014177
• Length: 274
• Species: Caenorhabditis elegans
• Alignment Length: 277
• Identity: 116/277 - (41%)
• Similarity: 161/277 - (58%)
• Gaps: 27/277 - (9%)

Human     2 AEYSYVKSTKLVLKGTKT------KSKKKKSKDKKRKREEDEETQLDIVGIWWTVTNFGEISG-- 58
            |:||.||...|.||..|.      |.||||:||.|.|.:.|....    |.|..:.:..::.|
 Worm     4 ADYSAVKGGGLKLKAGKKNLFKVGKEKKKKNKDDKEKIDPDTVEN----GGWRKIADEFDMKGGT 64

Human    59 TIAIEMDKG-----TYIHALDNGLFTLGAPHKEVDEGPSPPEQFTAVKL-SDSRIALKSGYGKYL 117
            .:|||:..|     ||:.|:|||.||:|.||.| .|||:|.|.|..||. .||:|:||:|:|:|:
 Worm    65 NVAIEVASGAGSTRTYVAAMDNGKFTIGFPHPE-GEGPNPEEIFALVKTPDDSKISLKTGFGRYV 128

Human   118 GINSDGLVVGRSDAIGPREQWEPVFQNGKMALLA-SNSCFIRC--NEAGDIEAKSKTAGEEEMIK 179
            |::|:..:|..::|||.|||:..|||.||.|..| |:..|:..  |:.|.|...|:||.|.||:.
 Worm   129 GVDSEYQLVAMAEAIGSREQFVLVFQEGKTAFQAVSSPLFLSTVPNKEGHIYVASRTATENEMVN 193

Human   180 IRSCAERETKKKDDIPEEDKGNVKQCEINYVKKFQ----SFQDHKLKISKEDSKILKKARKDGFL 240
            ||:.|.:| ...|....||:.|.::||..|||.:|    ..::..:.|..:|.|.:|||:.||..
 Worm   194 IRTDAIQE-GPVDWRSVEDRKNARECETAYVKMYQHSKVDLKNRHIAIDVKDKKGVKKAQADGSA 257

Human   241 HETLLDRRAKLKADRYC 257
            ||.|||||.|:|:||||
 Worm   258 HELLLDRRMKMKSDRYC 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRG1	NP_004468.1	Nuclear localization signal. /evidence=ECO:0000255	22..32		7/9 (78%)
		FRG1	67..256	CDD:368803	88/201 (44%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	235..251		9/15 (60%)
frg-1	NP_499696.2	FRG1	78..273	CDD:368803	87/196 (44%)