Protein Alignment Gclm and Akr1c6

DIOPT Version :10

• Sequence 1: NP_732780.1
• Gene: Gclm / 248194
• FlyBaseID: FBgn0046114
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_085114.1
• Gene: Akr1c6 / 83702
• MGIID: 1933427
• Length: 323
• Species: Mus musculus
• Alignment Length: 319
• Identity: 68/319 - (21%)
• Similarity: 115/319 - (36%)
• Gaps: 100/319 - (31%)

  Fly     8 KYQNVVISTGNII-----ATELGQRKSNEELYDGLKITL-----HTDSTAERVVVEKEID-ELHG 61
            |.|.|.:|.|:.|     .|...|.....:..:..||.:     |.|| |.....|||:. .:..
Mouse     4 KQQTVRLSDGHFIPILGFGTYAPQEVPKSKATEATKIAIDAGFRHIDS-ASMYQNEKEVGLAIRS 67

  Fly    62 RVQRATQELTTRLTENGRNEISIGAKIFLNRHSTESVNQAVEELLHILSVTHVDNVVLAYHPNAV 126
            ::...|.:         |.:|...:|::...|..|.|...:|:.|..|.:.:|| :.|.:.|.|:
Mouse    68 KIADGTVK---------REDIFYTSKVWCTFHRPELVRVCLEQSLKQLQLDYVD-LYLIHFPMAM 122

  Fly   127 ATATPVATTKPPCSEDSNVSRATNW--SQRNGK--EGVAELKELYKTLEQYALKQQITQLGIADL 187
                     ||          ..|:  ...|||  ....::.:.::.:|:.........:|:::.
Mouse   123 ---------KP----------GENYLPKDENGKLIYDAVDICDTWEAMEKCKDAGLAKSIGVSNF 168

  Fly   188 DAAALEEL-----------HNSAQVVPTIAQVNLSTCCVVPPELQEFCTAHDI------QLNTH- 234
            :...||::           .|..:..|.:.|          .:|.:||.:.||      .|.:|
Mouse   169 NRRQLEKILKKPGLKYKPVCNQVECHPYLNQ----------GKLLDFCRSKDIVLVAYSALGSHR 223

  Fly   235 -------SDPELL-LPV--------EQFDGLVPGYTIDWTLRYQVHVRCRGVLT-AKGY 276
                   |.|.|| .||        .:...|:       .||||:.   |||:. ||.:
Mouse   224 EKQWVDQSSPVLLDNPVLGSMAKKYNRTPALI-------ALRYQLQ---RGVVVLAKSF 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_732780.1	AKR_SF	<79..>235	CDD:444925	34/184 (18%)
Akr1c6	NP_085114.1	AKR_AKR1C1-35	6..308	CDD:381334	67/317 (21%)