Protein Alignment Gclm and AKR1B15

DIOPT Version :10

• Sequence 1: NP_732780.1
• Gene: Gclm / 248194
• FlyBaseID: FBgn0046114
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_001074007.2
• Gene: AKR1B15 / 441282
• HGNCID: 37281
• Length: 344
• Species: Homo sapiens
• Alignment Length: 252
• Identity: 51/252 - (20%)
• Similarity: 92/252 - (36%)
• Gaps: 70/252 - (27%)

  Fly    36 GLKITLHTDST-------------------AERVVVEKE---ID-----ELHGRVQRATQELTTR 73
            |||.:|..|:|                   |.:|.::.|   ||     |....|..|.||   :
Human    29 GLKSSLLKDTTSAGPLLRPYPASLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE---K 90

  Fly    74 LTENG--RNEISIGAKIFLNRHSTESVNQAVEELLHILSVTHVDNVVLAYHPNAVATATPVATTK 136
            :.|..  |.::.|.:|::........|.:|.|:.|..|.::::| |.|.:.|....|.....
Human    91 IQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLD-VYLIHWPQGFKTGDDFF--- 151

  Fly   137 PPCSEDSNVSRATNWSQRNGKEGVAELKELYKTLEQYALKQQITQLGIADLDAAALEELHN--SA 199
             |..:..|:.           .|.....:.::.:|:...:..:..||:::.:...:|.|.|  ..
Human   152 -PKDDKGNMI-----------SGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGL 204

  Fly   200 QVVPTIAQVNLSTCC---VVPPELQEFCTAHDIQLNTHS-------------DPELL 240
            :..|...||.    |   :...:|.::|.:..|.:..:|             ||.||
Human   205 KYKPVTNQVE----CHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLL 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_732780.1	AKR_SF	<79..>235	CDD:444925	29/160 (18%)
AKR1B15	NP_001074007.2	AKR_AKR1B1-19	51..344	CDD:381333	45/230 (20%)