DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gclm and GCLM

DIOPT Version :9

Sequence 1:	NP_001262845.1	Gene:	Gclm / 248194	FlyBaseID:	FBgn0046114	Length:	285	Species:	Drosophila melanogaster
Sequence 2:	XP_016856545.1	Gene:	GCLM / 2730	HGNCID:	4312	Length:	275	Species:	Homo sapiens

Alignment Length:	231	Identity:	68/231 - (29%)
Similarity:	115/231 - (49%)	Gaps:	38/231 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ISTGNIIATELGQRK----SNEELYDGLKITLHTDSTAERVVVEKEI-DELHGRVQRATQELTTR 73
            :.|||::.....::|    .:|||:|.::.||:..|:.....:.:|. |.|...|..|.:    :
Human    20 LQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVE----K 80

  Fly    74 LTENGRNEISIGAKIFL-NRHSTESVNQAVEELLHILSVTHVDNVVLAYHPNAVATATPVATTKP 137
            :..:.|.|:.:.||:|: ..:|:.|...||:....:|.|..:|:|::|               .|
Human    81 INPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIA---------------SP 130

  Fly   138 PCSEDSNVSRATNWSQRNGKEGVAELKELYKTLEQYALKQQITQLGIADLDAAALEELHNSAQVV 202
            |..:..|:|             :..|:..::.||.....::|..:|.:|||...||:|:..|||.
Human   131 PIEDGVNLS-------------LEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVK 182

  Fly   203 PTIAQVNLSTCCVVPPELQEFCTAHDIQLNTHSDPE 238
            |...||||::|||:||:|..|....||||.||:||:
Human   183 PNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPK 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_001262845.1	Aldo_ket_red	<79..>238	CDD:294321	51/159 (32%)
GCLM	XP_016856545.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158929
Domainoid	1	1.000	78	1.000	Domainoid score	I8810
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1557
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4802
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48881
OrthoDB	1	1.010	-	-		D1516283at2759
OrthoFinder	1	1.000	-	-		FOG0006260
OrthoInspector	1	1.000	-	-		oto90991
orthoMCL	1	0.900	-	-		OOG6_106072
Panther	1	1.100	-	-	LDO	PTHR13295
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4224
SonicParanoid	1	1.000	-	-		X5208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800