Protein Alignment Gclm and Akr1b1

DIOPT Version :10

• Sequence 1: NP_732780.1
• Gene: Gclm / 248194
• FlyBaseID: FBgn0046114
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_036630.1
• Gene: Akr1b1 / 24192
• RGDID: 2092
• Length: 316
• Species: Rattus norvegicus
• Alignment Length: 248
• Identity: 49/248 - (19%)
• Similarity: 92/248 - (37%)
• Gaps: 67/248 - (27%)

  Fly    24 LGQRKSNE-ELYDGLKITL-----HTDSTAERVVVEKEIDELHGRVQRATQELTTRLTEN--GRN 80
            ||..||.. ::.:.:|:.:     |.| .|:....|||:..       |.||   :|.|.  .|.
  Rat    18 LGTWKSPPGQVTEAVKVAIDMGYRHID-CAQVYQNEKEVGV-------ALQE---KLKEQVVKRQ 71

  Fly    81 EISIGAKIFLNRHSTESVNQAVEELLHILSVTHVDNVVLAYHPNAVATATPVATTKP-----PCS 140
            ::.|.:|::...|....|..|.::.|..|.:.::| :.|.:.|...         ||     |..
  Rat    72 DLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLD-LYLIHWPTGF---------KPGPDYFPLD 126

  Fly   141 EDSNVSRATNWSQRNGKEGVAELKELYKTLEQYALKQQITQLGIADLDAAALEELHN--SAQVVP 203
            ...||..:.           .:..:.:..:||...:..:..:|:::.:...:|.:.|  ..:..|
  Rat   127 ASGNVIPSD-----------TDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP 180

  Fly   204 TIAQVNLSTCC---VVPPELQEFCTAHDIQLNTHS-------------DPELL 240
            .:.|:.    |   :...:|.|:|....|.:..:|             ||.||
  Rat   181 AVNQIE----CHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLL 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_732780.1	AKR_SF	<79..>235	CDD:444925	28/165 (17%)
Akr1b1	NP_036630.1	AKR_AKR1B1-19	10..315	CDD:381333	49/248 (20%)