Protein Alignment Gclm and AKR1B1

DIOPT Version :9

• Sequence 1: NP_001262845.1
• Gene: Gclm / 248194
• FlyBaseID: FBgn0046114
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_001619.1
• Gene: AKR1B1 / 231
• HGNCID: 381
• Length: 316
• Species: Homo sapiens
• Alignment Length: 247
• Identity: 48/247 - (19%)
• Similarity: 95/247 - (38%)
• Gaps: 65/247 - (26%)

  Fly    24 LGQRKSNE-ELYDGLKITL-----HTDSTAERVVVEKEIDELHGRVQRATQELTTRLTENGRNEI 82
            ||..||.. ::.:.:|:.:     |.|...   |.:.| :|:...:|...:|...:     |.|:
Human    18 LGTWKSPPGQVTEAVKVAIDVGYRHIDCAH---VYQNE-NEVGVAIQEKLREQVVK-----REEL 73

  Fly    83 SIGAKIFLNRHSTESVNQAVEELLHILSVTHVDNVVLAYHPNAVATATPVATTKP-----PCSED 142
            .|.:|::...|....|..|.::.|..|.:.::| :.|.:.|...         ||     |..|.
Human    74 FIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLD-LYLIHWPTGF---------KPGKEFFPLDES 128

  Fly   143 SNVSRA-TNWSQRNGKEGVAELKELYKTLEQYALKQQITQLGIADLDAAALEELHN--SAQVVPT 204
            .||..: ||            :.:.:..:|:...:..:..:||::.:...:|.:.|  ..:..|.
Human   129 GNVVPSDTN------------ILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPA 181

  Fly   205 IAQVNLSTCC---VVPPELQEFCTAHDIQLNTHS-------------DPELL 240
            :.|:.    |   :...:|.::|.:..|.:..:|             ||.||
Human   182 VNQIE----CHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLL 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_001262845.1	Aldo_ket_red	<79..>238	CDD:294321	33/182 (18%)
AKR1B1	NP_001619.1	AKR_AKR1B1-19	10..316	CDD:381333	48/247 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900