Protein Alignment Gclm and AKR1C2

DIOPT Version :9

• Sequence 1: NP_001262845.1
• Gene: Gclm / 248194
• FlyBaseID: FBgn0046114
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_001345.1
• Gene: AKR1C2 / 1646
• HGNCID: 385
• Length: 323
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 67/313 - (21%)
• Similarity: 115/313 - (36%)
• Gaps: 88/313 - (28%)

  Fly     8 KYQNV---------VISTGNIIATELGQRKSNEELYDGLKITLHTDSTAERVVVEKEIDELH--G 61
            |||.|         |:..|.....|:.:.|:.|.:...::...|            .||..|  .
Human     4 KYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFH------------HIDSAHVYN 56

  Fly    62 RVQRATQELTTRLTENG--RNEISIGAKIFLNRHSTESVNQAVEELLHILSVTHVDNVVLAYHPN 124
            ..::....:.:::.:..  |.:|...:|::.|.|..|.|..|:|..|..|.:.:|| :.|.:.|.
Human    57 NEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVD-LYLIHFPV 120

  Fly   125 AVATATPVATTKPPCSEDSNVSRATNWSQRNGKEGVAELKELYKTLEQYALKQQITQLGIADLDA 189
            :|.....|.    |..|:..:...|           .:|...::.:|:.........:|:::.:.
Human   121 SVKPGEEVI----PKDENGKILFDT-----------VDLCATWEAMEKCKDAGLAKSIGVSNFNH 170

  Fly   190 AALEELHN--SAQVVPTIAQVNLSTCCVVPP-----ELQEFCTAHDIQLNTHS-----------D 236
            ..||.:.|  ..:..|...||...      |     :|.:||.:.||.|..:|           |
Human   171 RLLEMILNKPGLKYKPVCNQVECH------PYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVD 229

  Fly   237 PE--LLL--PV--------EQFDGLVPGYTIDWTLRYQVHVRCRGVLT-AKGY 276
            |.  :||  ||        ::...|:       .||||:.   |||:. ||.|
Human   230 PNSPVLLEDPVLCALAKKHKRTPALI-------ALRYQLQ---RGVVVLAKSY 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_001262845.1	Aldo_ket_red	<79..>238	CDD:294321	38/176 (22%)
AKR1C2	NP_001345.1	AKR_AKR1C1-35	6..308	CDD:381334	65/311 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900