Protein Alignment Gclm and AKR1C1

DIOPT Version :9

• Sequence 1: NP_001262845.1
• Gene: Gclm / 248194
• FlyBaseID: FBgn0046114
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_001344.2
• Gene: AKR1C1 / 1645
• HGNCID: 384
• Length: 323
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 72/323 - (22%)
• Similarity: 118/323 - (36%)
• Gaps: 108/323 - (33%)

  Fly     8 KYQNV---------VISTGNIIATELGQRKSNEELYDGLKITLHTDSTAERVVVE---KEIDELH 60
            |||.|         |:..|.....|:.:.|:.|               |.::.:|   :.||..|
Human     4 KYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALE---------------ATKLAIEAGFRHIDSAH 53

  Fly    61 --GRVQRATQELTTRLTENG--RNEISIGAKIFLNRHSTESVNQAVEELLHILSVTHVDNVVLAY 121
              ...::....:.:::.:..  |.:|...:|::.|.|..|.|..|:|..|..|.:.:|| :.|.:
Human    54 LYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVD-LYLIH 117

  Fly   122 HPNAVATATPVATTKPPCSED-----SNVSRATNWSQRNGKEGVAELKE--LYKTLEQYALKQQI 179
            .|.:|.....|.    |..|:     ..|.....|      |.|.:.|:  |.|:
Human   118 FPVSVKPGEEVI----PKDENGKILFDTVDLCATW------EAVEKCKDAGLAKS---------- 162

  Fly   180 TQLGIADLDAAALEELHN--SAQVVPTIAQVNLSTCCVVPP-----ELQEFCTAHDIQLNTHS-- 235
              :|:::.:...||.:.|  ..:..|...||...      |     :|.:||.:.||.|..:|
Human   163 --IGVSNFNRRQLEMILNKPGLKYKPVCNQVECH------PYFNQRKLLDFCKSKDIVLVAYSAL 219

  Fly   236 ---------DPE--LLL--PV--------EQFDGLVPGYTIDWTLRYQVHVRCRGVLT-AKGY 276
                     ||.  :||  ||        ::...|:       .||||:.   |||:. ||.|
Human   220 GSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALI-------ALRYQLQ---RGVVVLAKSY 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_001262845.1	Aldo_ket_red	<79..>238	CDD:294321	42/183 (23%)
AKR1C1	NP_001344.2	AKR_AKR1C1-35	6..308	CDD:381334	70/321 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900