Protein Alignment Gclm and Akr1c18

DIOPT Version :10

• Sequence 1: NP_732780.1
• Gene: Gclm / 248194
• FlyBaseID: FBgn0046114
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_598827.1
• Gene: Akr1c18 / 105349
• MGIID: 2145420
• Length: 323
• Species: Mus musculus
• Alignment Length: 322
• Identity: 63/322 - (19%)
• Similarity: 118/322 - (36%)
• Gaps: 100/322 - (31%)

  Fly     5 ITKKYQNVVISTGNII--------ATELGQRKSNEELYDGLKITL-----HTDSTAERVVVEKEI 56
            :..|.|.:.::.|:.|        |||...:|.:.|   ..||.:     |.|.:
Mouse     1 MNSKIQKIELNDGHSIPVLGFGTYATEEHLKKKSME---STKIAIDVGFCHIDCS---------- 52

  Fly    57 DELHGRVQRATQELTTRLTENG---RNEISIGAKIFLNRHSTESVNQAVEELLHILSVTHVDNVV 118
             .|:...:...|.:.::: |:|   |.:|...:|::...|..|.|..::|..|..|::.:|| :.
Mouse    53 -HLYQNEEEIGQAILSKI-EDGTVKREDIFYTSKLWSTSHRPELVRPSLENSLRKLNLDYVD-LY 114

  Fly   119 LAYHPNAVATATPVATTKP-----PCSEDSNVSRATNWSQRNGKEGVAELKELYKTLEQYALKQQ 178
            |.:.|         .:.||     |..|..|:...|           .:|.:.::.:|:......
Mouse   115 LIHFP---------VSLKPGNELLPKDEHGNLIFDT-----------VDLCDTWEAMEKCKDAGL 159

  Fly   179 ITQLGIADLDAAALEELHN--SAQVVPTIAQVNLSTCC---VVPPELQEFCTAHDIQLNTH---- 234
            ...:|:::.:...||.:.|  ..:..|...||.    |   :...:|..:|..:||.|..:
Mouse   160 AKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVE----CHLYLNQSKLLAYCKMNDIVLVAYGALG 220

  Fly   235 ----------------SDPELLLPVEQF---DGLVPGYTIDWTLRYQVHVRCRGVLT-AKGY 276
                            .||.|....:::   ..|:       .||||:.   ||::. ||.:
Mouse   221 TQRYKYCINEDTPVLLDDPVLCAMAKKYKRTPALI-------ALRYQLD---RGIVALAKSF 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_732780.1	AKR_SF	<79..>235	CDD:444925	34/185 (18%)
Akr1c18	NP_598827.1	AKR_AKR1C1-35	6..308	CDD:381334	62/317 (20%)