Protein Alignment Gclm and AKR1A1

DIOPT Version :10

• Sequence 1: NP_732780.1
• Gene: Gclm / 248194
• FlyBaseID: FBgn0046114
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_006057.1
• Gene: AKR1A1 / 10327
• HGNCID: 380
• Length: 325
• Species: Homo sapiens
• Alignment Length: 210
• Identity: 44/210 - (20%)
• Similarity: 84/210 - (40%)
• Gaps: 52/210 - (24%)

  Fly    79 RNEISIGAKIFLNRHSTESVNQAVEELLHILSVTHVDNVVLAYHPNAVATATPVATTKPPCSEDS 143
            |.|:.:.:|::..:|..|.|..|:.:.|..|.:.::| :.|.:.|.|
Human    72 REELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLD-LYLMHWPYA------------------ 117

  Fly   144 NVSRATNWSQRNGKEGV----AELKELYKTLEQYALKQQITQLGIADLDAAALEELHNSAQVVPT 204
             ..|..|...:|....:    ...||.:|.||....|..:..||:::.::..::::.:.|.|.|.
Human   118 -FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181

  Fly   205 IAQVNLSTCC---VVPPELQEFCTAHDIQLNTHS----------DPE--------LLLPVEQFDG 248
            :.||.    |   :...||...|.|..:::..:|          ||:        ::|.:.:..|
Human   182 VLQVE----CHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 242

  Fly   249 LVPGYTIDWTLRYQV 263
            ..|...:   ||:||
Human   243 RSPAQIL---LRWQV 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_732780.1	AKR_SF	<79..>235	CDD:444925	34/162 (21%)
AKR1A1	NP_006057.1	AKR_AKR1A1-4	8..312	CDD:381332	44/210 (21%)