DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gos28 and GOSR1

DIOPT Version :9

Sequence 1:	NP_650739.2	Gene:	Gos28 / 248102	FlyBaseID:	FBgn0044871	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	XP_005258127.1	Gene:	GOSR1 / 9527	HGNCID:	4430	Length:	300	Species:	Homo sapiens

Alignment Length:	240	Identity:	112/240 - (46%)
Similarity:	157/240 - (65%)	Gaps:	17/240 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LRKQARSLENEIDLKLVAFSKI----GAGSGGGGSGGLGGVDTSPLLG----EHVFDSLSEEIEQ 65
            ||||||.||||:|||||:|||:    ...|...|.......||:|||.    :.:|::::.||||
Human    62 LRKQARQLENELDLKLVSFSKLCTSYSHSSTRDGRRDRYSSDTTPLLNGSSQDRMFETMAIEIEQ 126

  Fly    66 MLEKLSSLNESMSD------LPASGAAAMHTLQRHREILQGYRQEFNKICANHTMRIEREELLRG 124
            :|.:|:.:|:.|::      :|:..||.||||||||:|||.|..||:|..||. |.|...|.|.|
Human   127 LLARLTGVNDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANF-MAIRERENLMG 190

  Fly   125 SGLATSSGSPSISGLNRR--EMYLKESGHLNSASHLVNDQINIAIETRDHLHAQRQAFKRLQTRF 187
            |.........|.||:|.|  |::|||..||.::..|:.:.|:||:.|::::.:||...|.:.::.
Human   191 SVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKM 255

  Fly   188 NDISNRFPLISSLIQRINIKKRRDSLILGAVIGFCVILLLLYAFN 232
            |.::||||.::|||||||::|||||||||.|||.|.||||||||:
Human   256 NTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gos28	NP_650739.2	SNARE	142..207	CDD:419871	27/66 (41%)
GOSR1	XP_005258127.1	SNARE_GS28	210..275	CDD:277217	26/64 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143149
Domainoid	1	1.000	101	1.000	Domainoid score	I6979
eggNOG	1	0.900	-	-		E1_KOG3208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37977
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3821
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55290
OrthoDB	1	1.010	-	-		D1319902at2759
OrthoFinder	1	1.000	-	-		FOG0004151
OrthoInspector	1	1.000	-	-		oto89790
orthoMCL	1	0.900	-	-		OOG6_102989
Panther	1	1.100	-	-	LDO	PTHR21094
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R505
SonicParanoid	1	1.000	-	-		X5179
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800