DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gos28 and GOS1

DIOPT Version :9

Sequence 1:	NP_650739.2	Gene:	Gos28 / 248102	FlyBaseID:	FBgn0044871	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_011832.1	Gene:	GOS1 / 856354	SGDID:	S000001023	Length:	223	Species:	Saccharomyces cerevisiae

Alignment Length:	227	Identity:	50/227 - (22%)
Similarity:	103/227 - (45%)	Gaps:	18/227 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SYDVLRKQARSLENEIDLKLVAFSKIGAGSGGGGSGGLGGVDTSPLLGEHVFDSLSEEIEQMLEK 69
            |:..:|.:|.|||.:.:..|..:|.....:....:|....:|          ..|...:.|..:.
Yeast     6 SFVTIRGKAISLETQTESLLSKYSTFAQTTSSEQTGQEKKID----------KQLEGILGQRQDV 60

  Fly    70 LSSLNESMSDLPASGAAAMHTLQRHREILQGYRQEFNKICANHTMRIEREEL-----LRGSGLAT 129
            :.||.:.....||..|:.:..|.||:||||.:.:.|..|  ..:::.||..|     ::.....:
Yeast    61 IDSLTQICDSNPAISASKLSQLHRHKEILQDHWKSFRNI--RSSIQQERNRLNLLFSVKNDIANS 123

  Fly   130 SSGSPSISGLNRREMYLKESGHLNSASHLVNDQINIAIETRDHLHAQRQAFKRLQTRFNDISNRF 194
            ::.:|:..| :..|....|:..::.::::|:..|:.|.|||...|:|.........:......|.
Yeast   124 TTDAPAPIG-DADEYIQNETRRIDQSNNVVDRLISQAWETRSQFHSQSNVLNTANNKVLQTLQRI 187

  Fly   195 PLISSLIQRINIKKRRDSLILGAVIGFCVILL 226
            |.::.||.:||.::::::.:|..:...|::.|
Yeast   188 PGVNQLIMKINTRRKKNAFVLATITTLCILFL 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gos28	NP_650739.2	SNARE	142..207	CDD:419871	16/64 (25%)
GOS1	NP_011832.1	V-SNARE_C	136..201	CDD:289148	16/64 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37977
Inparanoid	1	1.050	66	1.000	Inparanoid score	I1733
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55290
OrthoFinder	1	1.000	-	-		FOG0004151
OrthoInspector	1	1.000	-	-		oto99541
orthoMCL	1	0.900	-	-		OOG6_102989
Panther	1	1.100	-	-	LDO	PTHR21094
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R505
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790