DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sp1 and Spps

DIOPT Version :10

Sequence 1:NP_036787.2 Gene:Sp1 / 24790 RGDID:3738 Length:786 Species:Rattus norvegicus
Sequence 2:NP_001262902.1 Gene:Spps / 42882 FlyBaseID:FBgn0039169 Length:985 Species:Drosophila melanogaster


Alignment Length:997 Identity:276/997 - (27%)
Similarity:363/997 - (36%) Gaps:352/997 - (35%)


- Green bases have known domain annotations that are detailed below.


  Rat    25 GGSG------NGGGAAFSQTRSSSTGSSSS--------------SGG---GGGQES--------- 57
            |||.      ||..||.|||:......:.:              :||   |.||.:         
  Fly    23 GGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMPPQFAGGAVAGNGQNAGMPQNMFQI 87

  Rat    58 -QPSPLALLAATCSR-IESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPT 120
             ||.|:..:...... |..||.|:.                .||..:...||.|...:.:|....
  Fly    88 VQPMPMQTVNIDGQEAIFIPNLNAQ----------------LATAQAVNFNGQQAFITPNGQILR 136

  Rat   121 SKEQSGN----------STNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQ 175
            :.:.:.|          ..||. |.|.::..|:.|....:..|..:|.||            |.|
  Fly   137 APQMAANPAASNCIQLQQLNGL-GQEQTQLITIPGTNIQIPVTNLIQQQQ------------QAQ 188

  Rat   176 VIPQFQTVDGQQLQ----FAATGAQVQQDG-SGQIQ---IIPGANQQI----------------I 216
            .:.| .||. ||.|    ..|.|:.|...| :||:.   .|||.|.||                |
  Fly   189 QVHQ-GTVQ-QQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANGLLGNISNI 251

  Rat   217 TNRGSGGNII------------------AAMPNLLQQAVPLQGLANNVLSGQTQYVT-NVPVALN 262
            :|...||..|                  .|||. .||.|.:| :.....:|||.|.| :|||   
  Fly   252 SNLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQ-QQQTVAVQ-IPVQTANGQTIYQTVHVPV--- 311

  Rat   263 GNITLLPVNSVSAATLTPSSQAGTISSSGSQESGSQPVTSGTAISSASLVSSQASSSSFFTNANS 327
                                ||...||.|.|          ..:.:.||....||........:.
  Fly   312 --------------------QAAATSSGGLQ----------NLMQAQSLQMPSASQMQIIPQFSQ 346

  Rat   328 YSTTTTTSNMGIMNFTSSGSSGTSSQGQTSQRVGGL-QGSDSLNIQ----------QNQTSGGSL 381
            .:...|             .:|...|.|.:.....| ..::.::||          |.|......
  Fly   347 IAQIVT-------------PNGQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQA 398

  Rat   382 QGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQN 446
            |..||.:.:|:||.||||:..|.|     |.|||:..|...||....|.|:....|..||..:  
  Fly   399 QQQQQAQQQQAQQQQQQQVQAQHQ-----QLLQAISDASAGGQLPPNQPITITNAQGQQLTVI-- 456

  Rat   447 SGPIIIR-----TPTVGPNG------QVSWQTLQLQNL----QVQ-------------------- 476
              |..:|     .||..|.|      ..:.|.|.:||:    |||                    
  Fly   457 --PAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLT 519

  Rat   477 -----NPQAQT---ITLAPMQG--------VSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLS 525
                 :||.||   :.:.|.|.        .|:.|....  |..||::..:.||...|.|.|.  
  Fly   520 QLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPD--TFGPISATGNPPAPASTPNTAS-- 580

  Rat   526 SMPGLQTI--------NLSALG-TSGIQVHQLPGLPLAIANTPG-------------------DH 562
              |..|.|        :||:|. .:.||:..||.......|||.                   ..
  Fly   581 --PQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTS 643

  Rat   563 GAQLGLHGPGGDGIHDET----------------------------------------AGGEEGE 587
            ..|:.:...||..:...|                                        .||..|.
  Fly   644 STQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGT 708

  Rat   588 NSPDPQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHT 652
            .:.:|:|    |.:|.|||||.|.|.|....    ||:||||||.||.|||||||||||||||||
  Fly   709 ATGEPKP----RLKRVACTCPNCTDGEKHSD----KKRQHICHITGCHKVYGKTSHLRAHLRWHT 765

  Rat   653 GERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTH-------- 709
            |||||:|:|::||||||||||||||:|||||||:|.|.||.|:||||||||||||||        
  Fly   766 GERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVE 830

  Rat   710 -------QNKKGG---PGVALSVGTLPLD-SGAGSEGSGTATPSALITTNMVAMEAICPEGIARL 763
                   |..|||   ..::...|.:.:: .|.||..:|:...|...|   ||...:.|.|..  
  Fly   831 LIELSIKQETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSGASSVAAT---VAGSTVTPGGAT-- 890

  Rat   764 ANSGINVMQVTELQSINISGNG 785
                     :.:|.::..||.|
  Fly   891 ---------IVQLPTVEASGGG 903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sp1NP_036787.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..94 22/102 (22%)
Repressor domain. /evidence=ECO:0000250 2..83 22/91 (24%)
SP1_N 55..628 CDD:411775 172/766 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..143 6/42 (14%)
Transactivation domain A (Gln-rich). /evidence=ECO:0000250 147..252 38/146 (26%)
Transactivation domain B (Gln-rich). /evidence=ECO:0000250 262..496 63/295 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..303 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..397 15/75 (20%)
9aaTAD. /evidence=ECO:0000250|UniProtKB:P08047 463..471 2/7 (29%)
Transactivation domain C (highly charged). /evidence=ECO:0000250 497..611 37/181 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 562..600 9/77 (12%)
VZV IE62-binding. /evidence=ECO:0000250 620..786 93/185 (50%)
zf-C2H2 627..651 CDD:395048 21/23 (91%)
C2H2 Zn finger 629..651 CDD:275368 19/21 (90%)
zf-H2C2_2 643..670 CDD:463886 22/26 (85%)
C2H2 Zn finger 659..681 CDD:275368 17/21 (81%)
zf-H2C2_2 673..696 CDD:463886 17/22 (77%)
zf-C2H2 687..709 CDD:395048 17/21 (81%)
C2H2 Zn finger 689..709 CDD:275368 16/19 (84%)
Domain D. /evidence=ECO:0000250 709..786 20/96 (21%)
SppsNP_001262902.1 SP1-4_N <281..>371 CDD:425404 30/137 (22%)
Atrophin-1 284..>630 CDD:460830 97/408 (24%)
SP1-4_N <713..741 CDD:425404 15/35 (43%)
C2H2 Zn finger 742..764 CDD:275368 19/21 (90%)
zf-H2C2_2 756..783 CDD:463886 22/26 (85%)
C2H2 Zn finger 772..794 CDD:275368 17/21 (81%)
zf-H2C2_2 786..809 CDD:463886 17/22 (77%)
zf-C2H2 800..822 CDD:395048 17/21 (81%)
C2H2 Zn finger 802..822 CDD:275368 16/19 (84%)

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