DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc2a1 and CG1213

DIOPT Version :9

Sequence 1:	NP_620182.1	Gene:	Slc2a1 / 24778	RGDID:	3704	Length:	492	Species:	Rattus norvegicus
Sequence 2:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	141/488 - (28%)
Similarity:	213/488 - (43%)	Gaps:	62/488 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESI--------- 56
            |.|...| :||:.:|...|.|.:...|...|                |....|..:
  Fly    32 MSPEPVK-SGRIFMAAVAANLSAFVVGTTLG----------------WTSPIGPKLKSEDTSDSP 79

  Rat    57 ---PSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKS 118
               |.|:....|..|  :.:||.::..|..|...:|.||: .:|:.:.|.||.|  .|.:.:...
  Fly    80 LSRPITSDEDAWISS--LIAVGALVAPFVAGPMADRIGRK-WVLLSSSLFFVLA--FGLNMVASE 139

  Rat   119 FEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNA 183
            ..:|.:.|.|.|...|......||||||:|...:|||.|:|.||.||.|||.....| ..:...|
  Fly   140 VWILYMSRLIQGFGVGFVMTVQPMYVGEISTDNVRGATGSLMQLFIVGGILYVYAIG-PYVSYQA 203

  Rat   184 DLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTA-----DVTRDLQE 243
            ..|    ..|.:|.:...:.. ..||||.| ...:..::.|...|:.|||.:     |...::|.
  Fly   204 LQW----CCIVVPVVFDLVFY-MMPESPYF-FAGKGRKSEALKSLQFLRGQSAEGVHDEMAEIQA 262

  Rat   244 MKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGV-QQPV 307
            ..||.    ...|.|:::||::...|:.:.|...|...|||||||.|.:.|.|||..|.. ..|.
  Fly   263 NVEEA----MASKGTVMDLFKNAGNRRALFICAGLISFQQLSGINVVLFNSQSIFASANTGLDPA 323

  Rat   308 YATIGSGIVNTAFTVVSLFVVERAGRRTLHL-------IGLAGMAGCAVLMTIALALLEQLPWMS 365
            .|||..|.|....:.::..|.:|.||:.:.|       ||||.: |....|.:....:..:.||.
  Fly   324 IATIIIGCVQVGSSALTPLVADRLGRKVMLLTSSSVMSIGLAAL-GAFFYMQLVKGDISSVVWMP 387

  Rat   366 YLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCG 430
            ..::: |:..|  :..|.||:||.::.|:|....:..|.:|...:.||..|:|...:..::.|..
  Fly   388 VPALI-IYNIV--YCTGFGPLPWAVLGEMFPANIKSVASSVVASTCWTLGFLVTFFYPSLDALGS 449

  Rat   431 PYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEI 463
            .|.|.:|.|.:|:.|.|..|.|.||||.:..:|
  Fly   450 YYAFWLFAVCMVVAFFFVLFVVMETKGLSLQQI 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc2a1	NP_620182.1	MFS_GLUT_Class1	14..458	CDD:340989	134/468 (29%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492
CG1213	NP_001246937.1	SP	42..482	CDD:273317	135/475 (28%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	125/448 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810