Protein Alignment Scnn1b and ppk26

DIOPT Version :10

• Sequence 1: NP_036780.1
• Gene: Scnn1b / 24767
• RGDID: 3640
• Length: 638
• Species: Rattus norvegicus
• Sequence 2: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 632
• Identity: 123/632 - (19%)
• Similarity: 222/632 - (35%)
• Gaps: 179/632 - (28%)

  Rat    13 RLQKGPGY-TYKELLVWYCNNTNTHGPKRIICEGPKKKAM-----WF--LLTLLFACLVC----- 64
            :::.|.|: ..|.::..||:.|..||.:.:   |.||:.:     |.  |:..:|.|:..
  Fly    57 QIKYGSGFQAAKAIIHEYCDYTTIHGIRYL---GEKKRPLLERLFWISVLVLSVFTCVKLTLNIW 118

  Rat    65 --WQWGVFIQTYLS-----WEVSVSLSMGFKTMNFPAVTVCNSSP-----FQYSKVKHLLKDLYK 117
              |.....|.::..     |::.           |||||||..:.     |.::...|.::|...
  Fly   119 DKWNNNPVIVSFAEKSTPVWQIP-----------FPAVTVCPETKTRREIFNFTDSYHQVRDFQS 172

  Rat   118 LMEAVLD-----KILAPKSSHTNTTSTLNFTIWNHT--PLVLID---ERNPDHPVVLNLFGDSHN 172
            .:..::|     |.|....|........:.|:.|.|  .:.:||   |.:|.       |.|::.
  Fly   173 NVSGIVDLSDKQKGLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPH-------FDDTYL 230

  Rat   173 SSNPAPGSTCNAQGCKVAMRLCSANGTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMG 237
            :                           |.:||..           ::.::||.:.:.:|  |:.
  Fly   231 N---------------------------CKWRNSP-----------VKCSDIFHKFVTED--GVC 255

  Rat   238 YAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEKALPSAN----------PGTEFG 292
            ::.:.:..|.:|..|     ...|.|.....|....:|.:.:....||:          ||...|
  Fly   256 FSFNSLSPAEIFRAE-----GIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNRVLGPGARAG 315

  Rat   293 LKLILDIGQEDYVPFL-ASTAGARLMLHE-------QRTY---PFIREEGIYAMAGTETSIGVLL 346
            |.|.:...:.|:.... ....|.:::||.       .:.|   ||.:|    .:......|....
  Fly   316 LYLFMGGAEIDFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRIPFDQE----VLISIRPKIITTS 376

  Rat   347 DKLQGKGEPYSP----CTMNGS-DVAIQNLYSDYNTTYSIQACLHSCFQDHMIHNCSCGHYLYPL 406
            |.|    :.|.|    |..... ::...|:||..|       |...|..:..:..|.|..:..|.
  Fly   377 DGL----KHYEPNRRQCYFQKERELRYFNIYSQSN-------CELECLANFTLTKCGCVKFSMPR 430

  Rat   407 PAGEKYCNNRDFPDWAYCYLSLQMSVVQRETCLSM--------------CKESCNDTQYKMTISM 457
            ......|.:....    ||...:..::.||....:              |..||....|:..||.
  Fly   431 NVNMPVCGDASLK----CYNQAEDELLLREFTQGLVNAGENTRGETECNCLPSCTSIAYEAEISQ 491

  Rat   458 ADWPSEASEDWILHVLSQERDQSSNITLSRKG--IVKLNIYFQEFNYRTIEESPANNIVWLLSNL 520
            ||:..:.       |::.:..:.......|:|  :.:::|:|:|..:.|...|........|:|.
  Fly   492 ADFDYKT-------VINTDSPEGKEEQSKRQGMKMSRVSIFFKEAQFLTSRRSELYGTTDFLANC 549

  Rat   521 GGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVASCKGLRRRRPQR 567
            ||..|.:||.|:|.::|       .|:...::|:::   ||.||..|
  Fly   550 GGLLGLFMGVSMLSIVE-------LIYFCTVRLISN---LRMRRKTR 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	121/623 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..620
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844	614..618
ppk26	NP_648125.3	ASC	74..570	CDD:459966	114/594 (19%)