back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scn2a and NaCP60E

DIOPT Version :9

Sequence 1:	NP_036779.2	Gene:	Scn2a / 24766	RGDID:	3632	Length:	2005	Species:	Rattus norvegicus
Sequence 2:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster

Alignment Length:	2640	Identity:	831/2640 - (31%)
Similarity:	1202/2640 - (45%)	Gaps:	866/2640 - (32%)

- Green bases have known domain annotations that are detailed below.

  Rat    17 FTRESLAAIEQRIAEEKAKRPKQERKDED--DENG--PKPNSDLEAGKSLPFIYGDIPPEMVSEP 77
            |..|...|..|.:|..:..:.|.|.:...  .|.|  |:..:.:|.|..||..:...|..|..:|
  Fly     8 FNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKP 72

  Rat    78 LEDLDPYYINKKTFIVLNK---GKAISRFSATSALYILTPFNPIRKLAIKILVHSLFNVLIMCTI 139
            ||::|. :|.::||.|::|   ...|.||:.|.:|::..|::|.|::.:.|..:..|:..:|.||
  Fly    73 LEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136

  Rat   140 LTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV 204
            |.||:|:.|:   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.|||..|.
  Fly   137 LFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYA 198

  Rat   205 TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQL 269
            |..:.:||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||:
  Fly   199 TIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQV 263

  Rat   270 FMGNLRNKCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTVNMFNWDEYIEDKSHFYFLEGQND 334
            :||.|||||::..|                .||.      .|:..:|..::.|..::.:.|.:.
  Fly   264 YMGELRNKCVRQVP----------------TDWT------NVSHTDWQIWVNDTDNWLYDEDEL- 305

  Rat   335 ALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK 399
            .:||||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|:|||:|.:.|...|.
  Fly   306 PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGP 370

  Rat   400 TYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAA 464
            ..:.||.:|:|.||||||||:|||||::|||:.:.|.||.:      :.:|:.
  Fly   371 MSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERK------KDLLDH------------ 417

  Rat   465 AAASAESRDFSGAGGIGVFSESSSV--ASKLSSKSEKEL--------------KNRRKKKKQKEQ 513
                   ||.|      .||...||  ..||:..::|::              |.||||.|..::
  Fly   418 -------RDDS------TFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKE 469

  Rat   514 A----------GEEEKEDAV--------RKSASEDSIRKKGFRFSLEGSRLTYE-----KRFSSP 555
            .          |::.|..:.        |.||:|            ..|.||.:     ::....
  Fly   470 GGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATE------------RPSALTMQAQKQYQQMEQQ 522

  Rat   556 HQSLLSIRGSLFSPRRNSRASLFSFKGRVKDIGSENDFADDEHSTFEDNDS--RRDSLFVPHRHG 618
            |:...|..|...:|...:.      |||:               :|:|:..  :..::..|..:.
  Fly   523 HKLAKSGSGGSNNPMAPTP------KGRI---------------SFQDSGMGVKNPNMLYPSDYK 566

  Rat   619 ERRPSNVSQASRASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSPVGQLLPEGTTTETEIRK 683
            .:..:|..|.|..|.|:       ...|:.|.:|||.                      :.|.:.
  Fly   567 GQLIANSGQPSSNSSGV-------NRESSQDDSGVVD----------------------DHEEQD 602

  Rat   684 RRSSSYHVS-MDLLEDPSRQRAM----SMASILTNTMEELEES------------RQKCPPCWYK 731
            ..:...||| ::|...|...|.:    ::|.|..:.:..|.:.            .:.|
  Fly   603 TTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNC------ 661

  Rat   732 FANMCLIWDCC--KPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVG 794
              :.|:.| |.  :.||:.::.:..||.||..:||||:||||||.|:||||:.|:|.|.:.|.||
  Fly   662 --DRCVHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVG 723

  Rat   795 NLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
            |.|||.|||.|..:|::|:.. .:|..||||||..||:.||:::....|:||||||..|||||.|
  Fly   724 NKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLK 787

  Rat   860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH 924
            ||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||:
  Fly   788 LAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWN 849

  Rat   925 MHDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
            .:||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:||
  Fly   850 FNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSF 914

  Rat   987 SSDNLAATDDD-NEMNNLQIAVGRM--------QKGIDFVKRKIREFIQKAFVRKQKA------- 1035
            :|:.|.:..:: .|.:.|..::.|:        |:..|..:||..|..|:..:..|:|
  Fly   915 NSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSH 979

  Rat  1036 --------------LDEIK-----------------------PLED------------------- 1044
                          |.|.|                       ||.|
  Fly   980 QAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPE 1044

  Rat  1045 ----------------------------------------------------------------- 1044

  Fly  1045 QIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQ 1109

  Rat  1045 ----------------------------LNNKKDSC----------------------------- 1052
                                        .|:::..|
  Fly  1110 QYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKY 1174

  Rat  1053 ------------------------------------ISNHTTIEIGKDLNYL---------KDGN 1072
                                                :..|::   |:.||.:         :.||
  Fly  1175 QKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSS---GQSLNSMSIEQDELLSQQGN 1236

  Rat  1073 -------------------------GT--------------TSGIGSSVEKYVVDESDY------ 1092
                                     ||              :|.:|....:.:|:.|::
  Fly  1237 LREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQS 1301

  Rat  1093 ------------------MSFINNPS--------------LTVT----------VPIALGESDFE 1115
                              :|.::.||              ..:|          |.:.|...|..
  Fly  1302 FEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSY 1366

  Rat  1116 NLNT-------------------------------EEFSSESDM--------------------- 1128
            :|::                               |:||..:::
  Fly  1367 DLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAA 1431

  Rat  1129 -----------------------------------------EESK---------EK--------- 1134
                                                     ||.|         ||
  Fly  1432 TSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGP 1496

  Rat  1135 ---------LNATSSSEG----------------------------------------------- 1143
                     |.:|:|.|.
  Fly  1497 DQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAA 1561

  Rat  1144 --------------------------------------------STVDIGAPAEGEQPEA----- 1159
                                                        ||:|..|..:..:.|:
  Fly  1562 LTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGA 1626

  Rat  1160 ---------------EPEESLEPEA---------------------------------------- 1169
                           |..:|..|:|
  Fly  1627 ADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDP 1691

  Rat  1170 -----------------CFTEDCVRK--FKC-----CQISIEEGKGKLWWNLRKTCYKIVEHNWF 1210
                             ||.:.|...  |:|     |   ::....|.|..:|.....:|:...|
  Fly  1692 MTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTVVDTPAF 1753

  Rat  1211 ETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWC 1275
            |.|::.:|..||..|.||||.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.|.
  Fly  1754 EWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWT 1818

  Rat  1276 WLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNV 1340
            .|||:||.||:.||....  ...|..::|||||||||||||:||::|||:|||||:.|||||.||
  Fly  1819 ILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNV 1881

  Rat  1341 LLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNF 1405
            |||||:||||||||||..|.|||:.|:| ..||:..::.||:..:|   ||.|.|  |.|.|:.|
  Fly  1882 LLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT--WINSKITF 1940

  Rat  1406 DNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
            |:||:|||:|||||||:|||::|..|||:|.|:|||:.|.|||.|:||||||:.|||||||||||
  Fly  1941 DHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIG 2005

  Rat  1471 VIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVF 1533
            |||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|....:.|
  Fly  2006 VIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRF 2070

  Rat  1534 DISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRHYYFTIGWNIFD 1598
            :|:|.:||.|||:||.:|..||...:..||...|..|..:|..|.::|::.||::|||:.||:||
  Fly  2071 EIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFD 2135

  Rat  1599 FVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
            |::|:.||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::||||||||
  Fly  2136 FLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNI 2200

  Rat  1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
            |.||.|:.|||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..::.. |
  Fly  2201 GALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-P 2264

  Rat  1729 PDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSED 1793
            |||||   .......|:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.||
  Fly  2265 PDCDP---FIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVED 2326

  Rat  1794 DFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDIL 1858
            |.||||..|.|:||.|||||.|.:||||.|:|||||.|:|||.|.|::.:||:..|::|||||||
  Fly  2327 DLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDIL 2391

  Rat  1859 FAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIVIQRAYRRYL 1920
            .|..|.|||...|.|   .|:.||:.:|....|::...|.:::|...|::|.:|..||..::.||
  Fly  2392 HALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYL 2456

  Rat  1921 LKQKVKKVSSIYKKDKGKEDEGTPIKEDIITDKLNENSTP 1960
            .:          |::|.:.:.|         |...:.|:|
  Fly  2457 RR----------KREKERSNSG---------DSATQTSSP 2477

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.