DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MTOR and Tor

DIOPT Version :9

Sequence 1:NP_001373429.1 Gene:MTOR / 2475 HGNCID:3942 Length:2549 Species:Homo sapiens
Sequence 2:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster


Alignment Length:2580 Identity:1385/2580 - (53%)
Similarity:1786/2580 - (69%) Gaps:157/2580 - (6%)


- Green bases have known domain annotations that are detailed below.


Human    17 SNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDAN 81
            |..||:|||.:||||||...:.||.::|..||..|||||||||..:|:|:.:||||.:|:::|.|
  Fly     2 STTSVVQQFVNGLKSRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMVNATDIN 66

Human    82 ERKGGILAIASLIGVEGGNATR--IGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEY 144
            |:|||.||:..||..||....|  |..:.|.||:||..||..|||:|::::.:||....:..|:.
  Fly    67 EKKGGALAMKCLINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADS 131

Human   145 VEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGA 209
            .:|::|:|.|.|..:|.|.|||:||.:||||||::||:|:|.:..||:.||.|::|||.||||.|
  Fly   132 FDFDIKKAFEVLRGERQEYRRHSAVFILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESA 196

Human   210 VAALRACLILTTQRE-PKEMQKPQWYRHTFEEAEKGFDETLAK---EKGMNRDDRIHGALLILNE 270
            ..||||.||:|.||| .|:..:|||||..::||...|:..|..   :||:.|||||||.|::.||
  Fly   197 GEALRAALIVTAQRESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNE 261

Human   271 LVRISSMEGERLREEMEEI---TQQQLVHDKY--CKDLMGFGTK-----PRHITPFTSFQAVQPQ 325
            |.|.::...||....::.:   ||    |:|:  .......|::     ||...||  ...:...
  Fly   262 LFRCANATWERRYTSLKTLFPKTQ----HNKFLEASSSSSMGSQLNTLVPRLKVPF--IDKLGST 320

Human   326 QSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQM 390
            |::     ||...|..    |.:...::..::||...:::::|.:..:|..||:.|.||:..:|.
  Fly   321 QTH-----LGEGEHHK----GVAKFASQHNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQ 376

Human   391 TILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVK-KEKERTAAFQALGLLSVAVRSEFKVYLPR 454
            .:|.:|||||||..:.|.: :|||..::|::..:: |||:||.|:..:|.::|||:|..:|:|..
  Fly   377 ALLQILPRLAAFNRAVFVE-KYLQTCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHLSS 440

Human   455 VLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTA 519
            ::..::.|||.||...||:  :.||..||.||::||.|:...|..|:|::||.|...|||||||.
  Fly   441 IMTSVKVALPSKDLTSKRK--VPVDPAVFACITLLAHAVKSEIADDVKDILEQMFYTGLSPALTV 503

Human   520 VLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKP--LRHPGMPKGLAHQLASPGLTTLPEASDVGSI 582
            .|.:||..:||||..|.:||:.:||.|||:|.  |.:..:|     .:|..|  :|.:..|..:.
  Fly   504 CLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTALP-----TIAIDG--SLMQNGDGATT 561

Human   583 TLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQT 647
            .|||:|||:|.||..::..||:.|||:|:..|.:|||:||.:||:|||..::.  |..:...|:|
  Fly   562 VLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAVQ--SSESMENSKT 624

Human   648 AVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAI 712
            ....|:.|:.:||:|.|||.|.::|..:|.||||.||..|||.|:|.:||:.|:|::|||||||:
  Fly   625 LSDTVSHVIERLLMVAITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAM 689

Human   713 CTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILK 777
            .|:|||||:|||:|||.||..:|:::|:|::||:.|.|||||:||.|||.:.||||..||.||||
  Fly   690 VTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILK 754

Human   778 ALILKLKDPDPDPNPGVINNVLATIGELAQVSG--LEMRKWVDELFIIIMDMLQDSSLLAKRQVA 840
            ||:.||.  :|:.|||||.|||.|||:||:|:|  .||..|.|:|..|:::||.|:....||.||
  Fly   755 ALVPKLH--EPESNPGVILNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSPDKRGVA 817

Human   841 LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGM 905
            |||||||:::||.||.||.|||.|:::|:|||||||.:..|||.|||||||||:||||||:|.|:
  Fly   818 LWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIRRETIRVLGLLGAMDPYKHKMNKGL 882

Human   906 IDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTM 970
            ||..:|...::.|:.| ..:|.|.||:|:|||||| .|||:||||::.|||||.||.:||..||.
  Fly   883 IDSQKDNVLIAYSDGK-VDESQDISTAELLVNMGN-ALDEYYPAVAIAALMRILRDPTLSTRHTS 945

Human   971 VVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIV 1035
            ||||:||||:|||:|||.:|.||:|..|:.:|..|..:||||||||.:||:|||.||..||.:|.
  Fly   946 VVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADNNLREFLFQQLAILVAFVKLHIISYMGDIF 1010

Human  1036 TLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAI 1100
            .|::|||.:||.:|:|:|.|||||.||||.||:.||.:|||.:|||..||||..|:|:.:||.|:
  Fly  1011 KLIKEFWTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRMVTRRLLQAL 1075

Human  1101 QLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQ 1165
            |.||:.|..||.|:|||||||||:|..|......||||::.|...|||||::||||||:||.||.
  Fly  1076 QKFGSTLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDA 1140

Human  1166 SPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPL 1230
            .||||..||.||.||..||||||.:|:|||.:.|.:|||....|:.|:.:|....||||.     
  Fly  1141 EPELRDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADS----- 1200

Human  1231 IYQHRMLRSGQGDALASGPVETGPM--------KKLHVSTINLQKAWGAARRVSKDDWLEWLRRL 1287
                  ..:|:.:...|......|.        |.|.|:|..|:.||...||||||||:|||:||
  Fly  1201 ------YGAGESELRPSRFKNNEPFVTDRNSNNKNLQVTTNELRTAWQVTRRVSKDDWVEWLKRL 1259

Human  1288 SLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAE 1352
            |:.|||:|.|.:||:|.:|||.|:.:.||||||||:|||:||:.|.::||.:|:..||...|:.|
  Fly  1260 SIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISCWTELSPDLKNELTQSLIQALQVTDMPE 1324

Human  1353 VTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLI 1417
            :|||:|||||||||.|:.|:|:...    |||.||..||||||||.|||.||.......:.||||
  Fly  1325 ITQTILNLAEFMEHCDRDPIPIETK----LLGTRAMACRAYAKALRYKEEEFLLREDSQVFESLI 1385

Human  1418 SINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMR 1482
            .|||||||.|||.|:|........||.:|..||||||.|::||..|::.:.|:..|.|..||.||
  Fly  1386 LINNKLQQREAAEGLLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDSSDLEARLGHMR 1450

Human  1483 CLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYR 1547
            ||||||:|.:|......:|.....|.:::...:||.|||||..|::|.||...||.||.||::||
  Fly  1451 CLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGSYYR 1515

Human  1548 AVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERR 1612
            ||||:|.|.|..||:.||:.|||||.|||:||||||.|||||||...||:||||||||||:||||
  Fly  1516 AVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKLIPERR 1580

Human  1613 EIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLL 1677
            |.::.:||:||||.||:||||::|:.|.||||.||||:.|||||||||.|||.|.|:|||||:||
  Fly  1581 EPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTLVMLL 1645

Human  1678 GVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQ----HAIATEDQQ 1738
            |.||....:.|||...|||||||.|.|..:.:..:|::.:.|||.|..|:..    .|:..:|| 
  Fly  1646 GTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQ- 1709

Human  1739 HKQELHKLMARCFLKLGEWQLNLQ-GINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVL 1802
                  :|||||:|::..||..|| .|....|...|:.:..||.:|.:||||||.||.|||:.| 
  Fly  1710 ------RLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVV- 1767

Human  1803 HYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQK 1867
              :.|..|.|:::    ..||::                ..|.||..:|:.              
  Fly  1768 --QAQKSALDKQQ----PPGASM----------------GMTMGSGLDSDL-------------- 1796

Human  1868 KVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQI 1932
                   ..:..|.|||||||||||||.:||:||||||:||||||||:..:|.|||:.|:|.|:|
  Fly  1797 -------MIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGMKLIEI 1854

Human  1933 DTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKN 1997
            :|||||||||||||||.|.|||:||||||.|||:.|||||:|||||||||.:.||.|||.|||.:
  Fly  1855 NTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDS 1919

Human  1998 MCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGP 2062
            |.:||.|||:||:|.|||||||||||||.||||||||||||||:||||||||:|||||||:||||
  Fly  1920 MRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGP 1984

Human  2063 QTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVS 2127
            ||||||||:|||||:|.||.||.::|..|..|.||.:|||:|||||::||:||||||||||.|||
  Fly  1985 QTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVS 2049

Human  2128 PKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDL 2192
            |||:.|:||||||||:|:|.|.:|||..|..:|||||||||||||.:.||||.::::||||||||
  Fly  2050 PKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDL 2114

Human  2193 RQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKK 2257
            ||||||||||.||||||.:||.:.|:||:||||||||||||||||||||||||||.||||||:||
  Fly  2115 RQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKK 2179

Human  2258 KILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTR 2322
            |:.||.|||.||..|||||||||||||||||||:..|.||||||||||||||||:||:||.||||
  Fly  2180 KVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTR 2244

Human  2323 SLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAM 2387
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||..||
  Fly  2245 SLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAM 2309

Human  2388 EVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYS-- 2450
            ||||::|.||.||.:||.|||.:|||:|||||||||||||||||:|.:.|||       |:.:  
  Fly  2310 EVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGN-------DAVAGA 2367

Human  2451 --------AGQSVEILDGVELGEPAHKK---TGTTVPESIHSFIGDGLVKPEALNKKAIQIINRV 2504
                    :|....:.:.||...|..|.   ..|.....:|:.:.|      ..|.||.|:|.||
  Fly  2368 GAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVAD------ETNSKASQVIKRV 2426

Human  2505 RDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW 2549
            :.||||.||..:.:::..:||||||:|||::||||||||||||||
  Fly  2427 KCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPFW 2471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MTORNP_001373429.1 Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398 1..651 262/652 (40%)
TEL1 363..2549 CDD:227365 1235/2216 (56%)
HEAT 16 637..683 18/45 (40%)
HEAT repeat 655..681 CDD:293787 12/25 (48%)
HEAT 17 686..724 23/37 (62%)
HEAT repeat 691..721 CDD:293787 18/29 (62%)
HEAT 18 727..766 20/38 (53%)
HEAT repeat 729..759 CDD:293787 15/29 (52%)
HEAT 19 769..811 26/43 (60%)
HEAT repeat 772..805 CDD:293787 21/32 (66%)
HEAT 20 814..853 19/38 (50%)
HEAT repeat 817..847 CDD:293787 15/29 (52%)
HEAT 21 857..893 24/35 (69%)
HEAT 22 894..942 24/47 (51%)
HEAT 23 943..988 31/44 (70%)
HEAT repeat 955..981 CDD:293787 18/25 (72%)
HEAT 24 989..1027 20/37 (54%)
HEAT repeat 993..1021 CDD:293787 14/27 (52%)
HEAT 25 1029..1068 22/38 (58%)
HEAT repeat 1033..1062 CDD:293787 15/28 (54%)
HEAT 26 1069..1105 19/35 (54%)
HEAT repeat 1073..1099 CDD:293787 14/25 (56%)
HEAT 27 1106..1144 20/37 (54%)
HEAT repeat 1111..1142 CDD:293787 17/30 (57%)
HEAT 28 1145..1188 29/42 (69%)
HEAT repeat 1154..1180 CDD:293787 17/25 (68%)
HEAT 29 1189..1225 14/35 (40%)
HEAT 30 1226..1273 10/54 (19%)
HEAT 31 1274..1311 24/36 (67%)
HEAT 32 1312..1345 17/32 (53%)
TPR 1 1346..1382 17/35 (49%)
TPR 2 1383..1408 17/24 (71%)
TPR 3 1409..1442 16/32 (50%)
TPR 4 1443..1473 13/29 (45%)
TPR 5 1474..1507 14/32 (44%)
TPR 6 1508..1541 14/32 (44%)
TPR 7 1542..1574 20/31 (65%)
TPR 8 1575..1614 31/38 (82%)
TPR 9 1615..1649 20/33 (61%)
TPR 10 1650..1693 27/42 (64%)
TPR 11 1694..1731 15/40 (38%)
TPR 12 1732..1786 18/54 (33%)
TPR 13 1787..1846 17/58 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867 7/54 (13%)
TPR 14 1898..1930 21/31 (68%)
TPR 15 1931..1970 30/38 (79%)
TPR 16 1971..2005 22/33 (67%)
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 2012..2144 104/131 (79%)
Interaction with MLST8 2258..2296 28/37 (76%)
TorNP_001260427.1 TEL1 308..2471 CDD:227365 1245/2268 (55%)
HEAT repeat 632..658 CDD:293787 12/25 (48%)
HEAT repeat 668..698 CDD:293787 18/29 (62%)
HEAT repeat 706..736 CDD:293787 15/29 (52%)
HEAT repeat 749..780 CDD:293787 21/32 (66%)
HEAT repeat 798..823 CDD:293787 12/24 (50%)
DUF3385 831..999 CDD:288698 102/169 (60%)
HEAT repeat 841..870 CDD:293787 19/28 (68%)
HEAT repeat 880..917 CDD:293787 17/38 (45%)
HEAT repeat 925..954 CDD:293787 18/28 (64%)
Rapamycin_bind 1937..2034 CDD:285924 75/96 (78%)
PIKKc_TOR 2075..2353 CDD:270713 228/277 (82%)
FATC 2440..2471 CDD:280430 21/30 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159451
Domainoid 1 1.000 649 1.000 Domainoid score I157
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3637
Inparanoid 1 1.050 2570 1.000 Inparanoid score I29
Isobase 1 0.950 - 0.896241 Normalized mean entropy S1632
OMA 1 1.010 - - QHG53650
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 1 1.000 - - FOG0003052
OrthoInspector 1 1.000 - - oto90254
orthoMCL 1 0.900 - - OOG6_100794
Panther 1 1.100 - - LDO PTHR11139
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1538
SonicParanoid 1 1.000 - - X2407
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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